潘托拉唑、阿莫西林、甲硝唑治疗消化性溃疡及清除幽门螺旋杆菌的疗效观察  

The efficacy of triad of pantoprazole, amoxicillin and metronicazole in the treatment of petic ulcer and eradication of Helicobacter pylori

作　　者：吴楠[1] 王寿九[1] 王盛根[1] 潘桂红[1] 

机构地区：[1]南京军医学院第四一四医院消化科,南京210015

出　　处：《上海医药》2001年第12期541-543,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的 :观察潘托拉唑、阿莫西林、甲硝唑三联短程治疗消化性溃疡及清除幽门螺旋杆菌 (HP)的疗效。方法 :2 2 9例经胃镜确诊的消化性溃疡伴HP感染的病人随机分为两组 ,治疗组用潘托拉唑、阿莫西林、甲硝唑三联疗法 ,对照组用奥美拉唑、阿莫西林、甲硝唑三联疗法。结果 :两组的溃疡愈合率、疼痛消失时间及HP根治率均无显著性差异 (P >0 .0 5 ) ,不良反应均轻微。结论 :潘托拉唑、阿莫西林。Objective: To investigate the efficacy of the triad of pantoprazole, amoxicillin and metronidazole in the treatment of peptic ulcer and eradication of Helicobacter pylori (HP). Methods:Two hundred and twenty-nine patients with peptic ulcer associated with HP infertion were assigned randomly into 2 groups: 120 patients (89 males and 31 females, aged 40.6±14.8 years) of treatment group received pantoprazole 40mg po, qd for 4 weeks while 109 patients (79 males and 30 females, aged 41.3±12.7 years) of the control group received omeprazole 20mg po, bid for 4 weeks. Every patient of the 2 groups received also amoxicillin 1000mg po, bid for 1 week and metronidazole 400mg po, bid for 1 week. Results:No significant differences were observed between the treatment and control groups in the rates of ulcer healing and pain relief on d3 and d7, the average time to pain disappearance and the eradication rate of HP (P all>0.05). The adverse reactions in the 2 groups were mild. Conclusion:The triad of pantoprazole, amoxicillin and metranidazole is a satisfactory therapy in the treatment of peptic ulcer and eradication of HP.

关 键 词：消化性溃疡 潘托拉唑 奥美拉唑 幽门螺旋杆菌 甲硝唑 质子泵抑制剂 

分 类 号：R573.1[医药卫生—消化系统]