抗中性粒细胞胞浆抗体对维吾尔族及汉族溃疡性结肠炎的诊断意义  

The diagnostic significance of antineutrophil cytoplasmic antibodies in patients of Uygur nationality and Han nationality with ulcerative colitis

作　　者：高峰[1] 王志凤[2] 

机构地区：[1]新疆维吾尔自治区人民医院消化科,乌鲁木齐830001 [2]新疆医科大学第一医院消化科,乌鲁木齐830001

出　　处：《中华消化杂志》2001年第10期611-613,共3页Chinese Journal of Digestion

摘　　要：目的　了解抗中性粒细胞胞浆抗体 (ANCA)在新疆地区维吾尔族 (维族 )及汉族溃疡性结肠炎 (UC)患者中的阳性率 ,确定其对维族及汉族UC的诊断及鉴别诊断意义 ,同时通过比较维族及汉族UC患者中ANCA的阳性率 ,了解是否存在同一地区不同种族UC的ANCA阳性率的差异 ,评价ANCA是UC遗传易感性标志的可能性。方法　用间接免疫荧光法检测UC患者 (维族 3 9例 ,汉族 3 1例 )、腹泻患者 (维族 3 0例 ,汉族 3 0例 )及健康对照者 (维族 3 0例 ,汉族 3 0例 )的血清ANCA ,比较不同组间及不同种族间ANCA的阳性率。结果　UC组中维族及汉族的ANCA阳性率与对照组相比 ,差异均有显著性 (P <0 .0 5 ) ;UC组中维族与汉族间的ANCA表达 ,差异亦有显著性 (P <0 .0 5 ) ,ANCA在维族与汉族UC中的阳性率与病变范围及病情程度无关 (P >0 .0 5 )。结论　ANCA对UC具有较高的敏感性及特异性 ,是UC诊断的一个辅助手段 ,并具有鉴别诊断意义。同时提示 ,ANCA可能为UC遗传易感性的标志。ObjectiveTo evaluate the status of ANCA(antineutrophil cytoplasmic antibodies) positivity in Uygur nationality and Han nationality patients with ulcerative colitis (UC); and the possibility of the ANCA as a genetic marker of susceptibility between Uygur and Han nationality patients with ulcerative colitis in the same area. MethodsSerum samples from 39 Uygur and 31 Han patients with UC, 30 Uygur and 30 Han patients with diarrhea of other causes, 30 Uygur and 30 Han subjects as healthy controls were examined for ANCA using indirect immunofluorescence. Results ANCA was detected in 24 of 39(61.5%) Uygur patients with UC, 11 of 30( 35.5%) Han patients with UC, 1 of 30(3.3%) Uygur patients with diarrhea of other causes, none of 30 Han patients nor in the two healthy controls. It showed that the positive rate in Uygur patients with UC was significantly higher than in Han patients with UC (P<0.05). There was no correlation between the presence of ANCA and the activity, extent of the disease (P>0.05). Conclusions ANCA is useful in distinguishing patients with UC from other diarrhea diseases. ANCA may be a potential marker of genetic susceptibility to UC.

关 键 词：抗中性粒细胞胞浆抗体 溃疡性结肠炎 鉴别诊断 维吾尔族 汉族 

分 类 号：R574.62[医药卫生—消化系统]