超选择性髂内动脉插管化疗的5-FU药物动力学研究  

To study the pharmacokinetics of 5-FU in superselection internal iliac artery catheterization chemotherapy(SIAC)

作　　者：蔡丽萍[1] 邬素芳[1] 夏春华[2] 

机构地区：[1]江西医学院一附院妇产科,南昌330006 [2]江西医学院临床药理研究所,南昌330006

出　　处：《江西医药》2001年第6期414-415,共2页Jiangxi Medical Journal

摘　　要：目的研究在超选择性髂内动脉插管联合用药化疗中,氟尿嘧啶的药代动力学,并与全身静脉化疗结果相比较。方法以高效液相色谱法测定氟尿嘧啶血药浓度,应用3P97软件处理数据,分别计算插管化疗与静脉化疗组的药代动力学参数,并进行统计学分析。结果选择性髂内动脉插管联合用药组与静脉化疗组两组药代动力学参数比较有显著性差异(P<0.01)。结论氟尿嘧啶在血浆中的药代动力学模型为一室开放模型,超选择性髂内动脉插管化疗优于全身静脉化疗。Objective To study the pharmacokinet-ics of5-FU in the patients who receive superse-lection internal ilia artery catheterization chemotherapy,and contrast the group which receive vein chemotherapy.Methods HPLC method was used to determine the concentrations of5-FU in plasma.The plasma concentration-time values was fitted to3P87program to get the pharmacokinetic parameters respectively.The parameters was treated with statistics analysis.Results There is notable difference between the two groups.Conclusion The concentration-time curves obtained are in line with1compartment model.The superselection in-ternal iliae artery catheterization chemotherapy is better than vein chemotherapy.

关 键 词：超选择性髂内动脉插管 化疗 氟尿嘧啶 妇科肿瘤 高效液相 药代动力学 

分 类 号：R730.53[医药卫生—肿瘤] R969.1[医药卫生—临床医学]