心肺复苏期间患者缺血-再灌流损伤的临床研究  

Clinical study of reperfusion injuries in patients during cardiopulmonary resuscitation

作　　者：王宇航[1] 史晓红[2] 许文凯[1] 秦望森[3] 周再贤[3] 张培荣[1] 王勇[1] 

机构地区：[1]河南省人民医院急诊科,郑州450003 [2]河南省人民医院神经内科,郑州450003 [3]河南省人民医院检验科,郑州450003

出　　处：《中华急诊医学杂志》2001年第6期370-372,共3页Chinese Journal of Emergency Medicine

基　　金：河南省医药卫生科学研究重点项目(No 9317)

摘　　要：目的　探讨心肺复苏期间患者缺血 再灌流损伤的机制。方法　 2 0例心搏骤停行心肺复苏术患者 ,根据复苏后有无自主循环分为缺血组 (8例 )和再灌流组 (12例 ) ,并于复苏前 ,复苏后即刻 ,15min、 30min时分别测定其血中丙二醛 (MDA)和超氧化物歧化酶 (SOD)的浓度 ,比较两组患者血中上述指标的动态变化 ,并设正常对照组。结果　再灌流组MDA浓度较心搏骤停前明显增高 ,尤以 30min时增高显著 ,且明显高于缺血组 ,SOD浓度较心搏骤停前明显下降 ,尤以复苏后即刻下降显著 ,且明显低于缺血组。缺血组实施心肺复苏术前后MDA、SOD浓度无明显变化。结论　MDA和SOD在缺血 再灌流损伤中起着重要作用 ,动态监测血中MDA。Objective To explore possible mechanisms of ischemia/reperfusion injuries in patients during cardiopulmonary resuscitation(CPR).Methods 20 patients with sudden cardiac arrest received CPR.They were divided into two groups.The 12 patients who regained heart beats were reperfusion group;the 8 patients who didnt regain heart beats were ischemia group.The concentrations of malondialdehyde(MDA),superoxide dismutase(SOD)were determined before CPR and 0,15,30minutes after CPR.Twenty healthy individuals were used as controls.Results In reperfusion group,MDA levels were significantly higher than before CPR and ischemia group;SOD levels were significantly lower than before CPR and ischemia group.There were no obvious changes before and after CPR in ischemia group.Conclusions MDA and SOD played an important role in ischemia/reperfusion injury.Dynamic mornitoring of MDA?SOD in CPR was worthwhile in order to assess the degree of reperfusion injuries.

关 键 词：心搏骤停 心肺复苏 缺血-再灌流损伤 丙二醛 超氧化物歧化酶 

分 类 号：R459.7[医药卫生—急诊医学]