乳腺肿瘤中端粒酶、C-erbB-2癌基因蛋白的表达及意义  

Study on the correlation about expression of telomerase and C-erbB-2 in breast tumor

作　　者：邱晓光[1] 许岩丽[1] 韩建军[1] 谷俊霞[1] 郭丽霞[1] 

机构地区：[1]邯郸医学高等专科学校,河北邯郸056002

出　　处：《中国实验诊断学》2001年第4期183-184,共2页Chinese Journal of Laboratory Diagnosis

基　　金：河北省教委基金资助项目 (982 31 )

摘　　要：目的　探讨分析端粒酶、C erbB 2癌基因蛋白在乳腺肿瘤中的表达及意义。方法　应用免疫组化等方法 ,对 16 5例患者分别进行检测。结果　端粒酶、C erbB 2主要表达于癌细胞中 ,均与腋淋巴结转移密切相关 (P <0 0 1)。且二者均在乳腺癌前病变中有表达。结论　二者联合 ,即可用于鉴别乳腺良、恶性病变 ,又可做为早期诊断指标 ,亦可用于判断预后。Objective To study the correlation about expression of telomerase and C-erbB-2 in breast tumor.Method One hunderd and sixty-five cases of breast disease were studied by immunohistochemical analysis.Result Expression of Telomerase and C-erbB-2 was in carcinoma cells and closely related with armpit lymph node's metastases (P<0.01). Particularly, they have expression in breastprecancerous lesion. Conclusion Telomerase and C-erbB-2 are not only used in distinguishing benign and malignant diseases but also regarded as early diagnosis target of breast cancer.

关 键 词：乳腺肿瘤 端粒酶 C-ERBB-2癌基因 

分 类 号：R737.9[医药卫生—肿瘤]