血管生成与肿瘤转移  

Angiogenesis and Tumor Metastasis

作　　者：赵建华[1] 

机构地区：[1]江苏省肿瘤防治研究所,江苏省临检中心,江苏南京210009

出　　处：《中国实验诊断学》2001年第4期201-204,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：肿瘤生长和转移是血管生成依赖性的 ,它分泌两类相拮抗的因子—血管生成刺激因子和抑制因子 ,刺激和抑制相互作用决定了肿瘤的血管生成活性。检测肿瘤组织或血清、尿等多种体液中血管生成刺激和抑制因子 ,可提供反映肿瘤血管生成活性的信息 ,有可能成为预示肿瘤发展、转移及预后的新的敏感指示剂。Angiogenesis plays a crucial role in tumor growth and metastases. It is becoming clear that many malignant tumors generate both stimulators and inhibitors of neovascularization, and a net balance between these position and negative regulators decides finally tumoral angiogenesis activation. Measuring the levels of some main stimulators and/or inhibitors of angiogenesis in solid tumors or in the serum or urine may reflect the information about tumor angiogenesis activation, further provides new and sensitive markers for tumor progression, metastasis and prognosis.

关 键 词：肿瘤 血管生成 刺激因子 抑制因子 

分 类 号：R730.2[医药卫生—肿瘤]