三叉神经痛患者血浆血管活性肠多肽的观察  

Observation on plasma vasoactive intestinal polypeptide in patients with trigeminal neuralgia

作　　者：赵云富[1] 姜晓钟[1] 刘渊[1] 胡世辉[2] 宋朝佑[3] 

机构地区：[1]第二军医大学长征医院口腔科,上海200003 [2]湖北省宜昌市第一人民医院口腔科 [3]第二军医大学神经生物学教研室

出　　处：《上海医学》2001年第12期746-748,共3页Shanghai Medical Journal

基　　金：'95全军医药卫生科研基金资助课题 ( 98M0 84);长征医院优秀青年科技人才 2 0 8培养基金赞助项目

摘　　要：目的　观察三叉神经痛发作时局部是否有血管活性肠多肽 (VIP)的参与 ,加深对三叉神经痛发病机制的认识。方法　三叉神经痛患者 16例 ,正常自愿者 10名 ,用放射免疫法测定疼痛发作时患侧颈外静脉血、肘静脉血及术后患侧颈外静脉血中VIP含量 ,以正常自愿者颈外静脉血中VIP的含量作为正常对照。结果　疼痛发作时患侧颈外静脉血中的VIP含量明显高于患者肘静脉血、术后患侧颈外静脉血及正常自愿者颈外静脉血中的VIP含量。结论　三叉神经痛发作时局部确有VIP参与 。Objective To observe whether vasoactive intestinal polypeptide(VIP) participates in the attack of trigeminal neuralgia, and get a deeper understanding about its pathogenetic mechanism. Methods Sixteen patients were studied. During the attacks and venous blood was sampled from both the external jugular vein and cubital fossa vein ipsilateral to the pain, and after operations the venous blood from the external jugular vein was sampled again, the external jugular vein blood of ten normal volunteers was collected as control. Plasma levels of VIP were determined using sensitive radioimmunoassay. Results During the attacks of trigeminal neuralgia the levels of VIP in the external jugular vein blood were significantly higher than that in the cubital fossa vein blood, postoperative external jugular vein blood and the external jugular vein blood of normal voluntters. Conclusion VIP indeed participate in the attack of trigeminal neuralgia in the local region, the role of VIP may be relating to enhancing substance P causes local neurogenic inflammation.

关 键 词：三叉神经痛 血管活性肠多肽 放射免疫测定 

分 类 号：R781.02[医药卫生—口腔医学]