肝细胞糖原对缺血再灌注肝细胞线粒体呼吸功能的影响及意义  

The Effect of Intracellular Glycogen on Mitochondrial Respiratory Function of the Ischemic and Reperfusive Hepatocytes and its Values

作　　者：汤礼军[1] 田伏洲[1] 王雨[1] 邢庆蓉[1] 高晓美[1] 

机构地区：[1]成都军区总医院全军普外中心实验室,四川成都610083

出　　处：《中国医师杂志》2001年第10期739-741,共3页Journal of Chinese Physician

摘　　要：目的　为探讨肝细胞糖原对缺血再灌注肝细胞线粒体呼吸功能的影响及意义。方法　对三组糖原含量显著不同的兔肝脏缺血再灌注过程中的组织ATP含量、肝脏酶学改变、肝细胞线粒体呼吸控制率 (respiratorycontrolratio ,RCR)及磷氧比率 (P/Oratio)进行测定。结果　糖原含量高的肝脏 ,组织ATP含量、肝细胞线粒体PCR及P/O越高 ,而肝功能损伤越轻。说明缺血前增加肝脏糖原负荷能显著改善肝细胞线粒体呼吸功能 。Objective To investigate the effect of intracellular glycogen on mitochondrial respiratory function of the ischemic reperfusion hepatocytes and its values.Methods During liver ischemia-reperfusion in the 21 rabbits,the tissue ATP content,hepatic enzymological change,respiratory control ratio(RCR) and P/O ratio of hepatocellular mitonchondria were observed in liver glycogen content significantly different three groups.Results Rabbit liver tissue with the higher content of glycogen has shown the higher mitonchondrial ATP content,also showed the higher RCR and P/O ratio of hepatocellular mitonchondria and the slighter injury of liver function.Conclusion Intracellular abundant glycogen may significantly improve respiratory functon of mitochondria,which can play an important role in keeping the hepatocellular function well during liver ischemia-reperfusion.

关 键 词：肝脏 线粒体 糖原 呼吸功能 缺血再灌注损伤 

分 类 号：R363[医药卫生—病理学]