脑星形细胞瘤中神经细胞黏附分子与PCNA的表达及其关系  

Expression of the neural cell adhesion molecule in human astrocytomas

作　　者：黄垂学[1] 胡守兴[1] 陈兵[1] 

机构地区：[1]中南大学湘雅二医院神经外科

出　　处：《湖南医科大学学报》2001年第6期543-545,共3页Bulletin of Hunan Medical University

摘　　要：目的 :研究人脑星形细胞瘤中神经细胞黏附分子 (neuralcelladhesionmolecule ,NCAM)的表达情况及其与肿瘤增殖活性 (PCNA)的相关性。方法 :收集人脑星形细胞瘤标本 48例 ,行SP法染色。结果 :正常脑组织NCAM全部表达 ,星形细胞瘤中I～II级、III级、IV级组阳性表达率分别为 95 % (1 9/ 2 0 ) ,3 8 9% (7/ 1 8)和 2 0 % (2 / 1 0 ) ,阳性细胞表达程度随肿瘤恶性程度的增高反而降低。其表达程度与PCNA免疫反应分数 (IRS)呈负相关 (r =- 0 .6 5 7,P <0 .0 5 )。结论 :随人脑星形细胞瘤恶性程度的增高 ,NCAM表达下调 ,提示NCAM表达减少参与肿瘤的生物恶性发展。Objective To investigate the expression of the neural cell adhesion molecule (NCAM) in human astrocytomas, and evaluate the relationship between NCAM and proliferating cell nuclear antigen (PCNA). Methods Forty-eight astrocytomas were studied by SP method with monoclonal antibody against NCAM and PCNA proteins. Results All normal brain tissues expressed NCAM; NCAM expression was positive in Grade I～II glioma [95%(19/20)], Grade III glioma [38.9%(7/18)], Grade IV glioma respectively. An inverse correlation was observed between the degree of NCAM expression and that of PCNA (r=-0.657, P<0.05). Conclussion NCAM is a down-regulated factor in the development of the malignancy of astrocytomas; and it is suggested that the reduced NCAM expression might be involved in the development of biological malignancy.

关 键 词：神经细胞黏附分子 增殖细胞核抗原 脑肿瘤 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]