SLE脑病死亡的临床与实验相关因素分析  

Analysis on clinical and laboratorial factors related to death of cerebropathy in patients with systemic lupus erythematosus

作　　者：许怀麟[1] 李希清[1] 陈宜芳[1] 许德清[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院皮肤科,510120

出　　处：《中国麻风皮肤病杂志》2001年第4期234-236,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的 :　探讨系统性红斑狼疮 (SLE)脑病死亡的临床与实验相关因素。方法 :　采用回顾性病例对照研究、多因素分析的方法 ,对 70例SLE脑病患者进行分析。结果 :　单因素分析结果提示补体C3 下降、A/G倒置、甲基泼尼松龙冲击疗法 3个因素是SLE脑病死亡的高危因素。Logistic多元回归分析结果示A/G倒置、甲基泼尼松龙冲击疗法 2个指标进入Logistic多元回归方程 (P =0 .0 0 13) ,OR值分别为3.470 2、4.5 336。结论 :　C3 下降、A/G倒置、甲基泼尼松龙冲击疗法 3个指标是SLE脑病死亡的高危因素 ,而后Objective:To analyze the clinical and laboratorial factors related to death of cerebropathy in patients with systemic lupus erythematosus. Methods:In a retrospective case control study, single and multi factors logistic regression analysis were used. Results:Single factor analysis revealed that decrease of serum complement 3 (C 3), serum albumin/globulin (A/G) inversion, methylprednisonlone pulse therapy were the risk factors related to the death of cerebropathy in SLE. But only seum A/G inversion and methylprednisonlone pulse therapy were significantly correlated with the death in multi factors logistic equation analysis. Conclusions : Serum A/G inversion and methylprednisonlone pulse therapy might be the most important risk factors. Thus the value of methylprednisonlone pulse therapy in cerebropathy of SLE should be further assessed. [

关 键 词：系统性红斑狼疮 脑病 相关因素 死亡 

分 类 号：R747.9[医药卫生—神经病学与精神病学]