血清总唾液酸判断脑胶质瘤治疗效果的作用  

Serum Total Sialic Acid Its Contribution to the Follow-up of Gliomas

作　　者：茹小红[1] 任新亮[1] 武金有[1] 冯祖荫[2] 徐国本[2] 侯卫红[3] 

机构地区：[1]长治医学院附属和济医院神经外科,046000 [2]河南医科大学一附院 [3]河南医科大学

出　　处：《长治医学院学报》2001年第4期269-270,共2页Journal of Changzhi Medical College

摘　　要：目的 :探讨血清总唾液酸 (totalsialicacid ,TSA)含量变化判断脑胶质瘤治疗效果的作用。方法 :采用王官将的快速测定法对正常对照组 73例 ,脑胶质瘤患者 2 1例术前术后 (均辅以放疗 )血清TSA含量进行检测。结果 :缓解期胶质瘤及复发性胶质瘤术前血清TSA含量均显著高于正常对照组 (P <0 .0 1 ) ,两实验组比较无显著性差异 ;术后一个月TSA均稍下降 (P <0 .0 1 ) ;经手术全切 1年内未复发者 9例 ,术后 6个月～ 1 2个月血清TSA含量显著低于术后 1个月 (P <0 .0 1 ) ,反之 ,经手术全切 1年内复发者及未全切者 1 2例 ,术后 6个月～ 1 2个月又升高 ,接近术前水平。结论Objective:To investigate the role of serum total sialic acid measurement for the follow -up of human brain gliomas.Method:Serum concentration of TSA were determined in 21 patient with brain glioma and in 73 healthy subjects.Result:The concentration of TSA was significantly increased in gliomas preopertively and fell to somewhat lower levels within 1 month after tumour resection.In 9 patients with complete tumor resection and no tumor recurrences within 1 years ,it was statistically lower.with complete tumor resection and no tumor recurrences within 1 years ,it was statisticallly lower.within 6～12 months after surgery than those in 1 month after tumour resection.whereas in patients with tumor recurrences or incomplete tumour resection it rose again within 6～12 months after tumour resection.Conclusion:Serum TSA determenation was prognostic value in the patient with brain gliomas.

关 键 词：血清 总唾液酸 脑胶质瘤 随访 疗效 

分 类 号：R739.41[医药卫生—肿瘤] R730.264[医药卫生—临床医学]