部分甲基化β-环糊精的研究  

The Study on Partly Methylated β-Cyclodextrin

作　　者：于淑丽[1] 于洪社 宋全道[3] 

机构地区：[1]山东省威海市文登中心医院,文登264400 [2]山东省威海卫生学校,文登264400 [3]山东大学药学院,济南250012

出　　处：《天津药学》2001年第6期41-43,共3页Tianjin Pharmacy

摘　　要：目的 :合成部分甲基化 β-环糊精 ,进行长期口服毒性实验 ,研究其对槲皮素的增溶作用。方法 :用红外光谱、薄层色谱等方法进行鉴定。结果 :部分甲基化β-环糊精长期口服无毒 ,与不溶于水的槲皮素形成包合物后 ,使槲皮素的溶解度增加到 0 .192 g/ L。结论 :部分甲基化Objective: To synthesize partly methylated β cyclodextrin and study the solubiliztion of quercetin by the β cyclodextrin derivative in the chronic oral toxicity of β cyclodextrinderivative in female mice. Methods: The derivative was elucidated by IR and thin layer chromatography. Results: Long term oral toxicity data for the β cyclodextrin derivative suggested that the β cyclodextrin derivative had no toxicity and the solubility of quercetin in inclusion complex was increased from water insoluble to 0.192 g/L. conclusion: The β cyclodextrin derivative can be used as the dissolution, enhancing excipient in tablets.

关 键 词：部分甲基化β-环糊精 槲皮素 增溶作用 长期口服毒性实验 

分 类 号：O636.12[理学—高分子化学] R965.3[理学—化学]