缺血预处置对家兔肢体缺血再灌注损伤的影响  

The Effect of Ischemic Preconditioning on the Limb Ischemia-reperfusion Injury in Rabbits

作　　者：千智斌[1] 姬明丽[1] 郝云霞[2] 

机构地区：[1]新乡医学院病理生理学教研室,453003 [2]河南省新乡市第一人民医院外一科

出　　处：《齐齐哈尔医学院学报》2001年第8期842-843,共2页Journal of Qiqihar Medical University

摘　　要：目的　观察缺血预处置的影响 ,研究PC对IR组织的保护作用。方法　复制家兔后肢缺血再灌注 (IR)的损伤模型 ,取不同组的血浆测定其LDH、CD、MDA、SOD的含量。结果　IR组织较对照组LDH、CD、MDA的含量均显著增高 ,SOD含量明显降低 ,IR +PC组LDH、CD、MDA含量增高及SOD含量下降程度均小于IR组。结论　PC对IR肢体具保护作用 ,其机制之一是减少细胞结构损伤及自由基的产生。Objective To study the effect of ischemic preconditioning(PC) to ischemia-reperfusion(IR).Methods We duplicated the model of limb ischemiareperfusion injury in rabbit,than the contents of LDH,CD,MDA,SOD were observed,and differences of grounds were analysed.Results The content of LDH,CD,MDA of IR group increased significally,and the action of SOD came down.These indexies of PC+IR group changed a little compared with IR group.Conclusions PC protected rabbit from limb IR injury.

关 键 词：缺血预处置 缺血再灌注损伤 自由基 肢体 家兔 

分 类 号：R364.1[医药卫生—病理学] R－332[医药卫生—基础医学]