中药对脊髓损伤大鼠背根神经节c-Jun表达的影响  

Effect of Chinese Herb on c-Jun Expression in Dorsal Root Ganglia in Rats with Spinal Cord Hemisection

作　　者：高秀来[1] 景鹏[1] 郝彦利[1] 马育平[1] 陈亚亮[1] 陆涛[1] 韩凤岳[2] 苏静[2] 刘卫东[2] 张平[2] 常超英[2] 刘恩[2] 

机构地区：[1]首都医科大学解剖学教研室 [2]中国中医研究院骨伤科研究所

出　　处：《首都医科大学学报》2001年第4期292-295,共4页Journal of Capital Medical University

基　　金：北京市教委 1997年基金资助项目

摘　　要：应用荧光免疫组化法及激光扫描共聚焦显微镜技术 ,探索中药脊髓Ⅰ号促进大鼠损伤脊髓修复再生的机制。结果表明 ,服用脊髓I号后脊髓损伤侧背根节神经元的c Jun表达明显上调 ;脊髓损伤侧背根节神经元的细胞核呈完整形态的数量明显增多。提示脊髓Ⅰ号可能通过对c Jun基因表达的调节 。The object was to study the mechanism of promoting spinal cord regeneration and repair in rats with SCI after spinal cord injury by fluorescence immunohistochemical method combined with laser scanning confocal microscopy. The results indicated that the up regulation of c Jun was heightened in dorsal root ganglia of the injury side by the administration of SCI and the number of nerve cells with intact nuclear in SCI administration group was higher. This study showed that SCI could regulate c Jun expression and promote regeneration of the spinal cord.

关 键 词：中药 背根神经节 脊髓损伤 C-JUN表达 

分 类 号：R274.932[医药卫生—中西医结合] R285.5[医药卫生—中医骨伤科学]