亚低温防治脑血管痉挛的实验研究  

Experimental Study on Subhypothermia against Cerebral Vasospasm

作　　者：杨绮帆[1] 李铁林[2] 钱锁开 姜晓丹[2] 黄连泉[1] 

机构地区：[1]解放军第94医院神经外科,江西南昌330002 [2]第一军医大学附属珠江医院神经外科,广东广州510282

出　　处：《现代诊断与治疗》2001年第4期196-199,共4页Modern Diagnosis and Treatment

基　　金：研究生课题部分

摘　　要：目的　研究兔蛛网膜下腔出血 (Subarachnoidhemorrhage ,SAH)后脑血管痉挛的发生发展过程和脑实质温度变化 ,探索亚低温对痉挛血管的影响和作用机制。方法　通过“枕大池二次注血”制作兔SAH模型并予亚低温处理。结果　33～ 35℃亚低温对SAH后动物生命体征无影响 ,却显著降低SAH后脑血管痉挛 (Cerebralvasospasm ,CVS)的频度和强度。结论　SAH后早期实施亚低温能有效抑制痉挛血管由功能改变向结构改变的转化 ,减轻血管组织的病理损害。Objective To investigate the developing course of cerebral vasospasm and the change of brain temperature following subarachnoid hemorrhage(SAH) in rabbits,the effects of subhypothermia on vasospasm.Method A SAH rabbit model was adopted by double injecting blood into foramina occipitale magnum and managed by subhypothermia.Results 33～35℃ subhypothermia has significant preventing effects on cerebral vasospasm(CVS) after SAH.Without any side effect on vital signs.Conclusions As early as carrying out subhypothermia can reduce and postpone CVS after SAH,and relieve the pathological damage of vessel tissue.

关 键 词：蛛网膜下腔出血 脑血管痉挛 亚低温 SAH 防治 

分 类 号：R743.35[医药卫生—神经病学与精神病学]