微囊化对大鼠胰岛细胞冻存后功能的影响  

Influence of Microencapsulation under Cryopreservation on the Function of Rat Pancreatic Islets

作　　者：李保国[1] 华泽钊[1] 王国兴[2] 张洪德[2] 王煜非[2] 

机构地区：[1]上海理工大学低温生物技术研究所,上海200093 [2]上海市第一人民医院,上海200080

出　　处：《中国医药工业杂志》2001年第11期503-505,共3页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金资助重点项目 (5 983 62 40 )

摘　　要：对 SD大鼠胰岛进行微囊化 ,并比较分析了微囊化与未微囊化大鼠胰岛冷冻保存后 ,胰岛损失率以及胰岛素分泌功能变化。微囊化胰岛冻存后胰岛损失率为未微囊化的 1/2 ;冷冻保存前后 ,微囊化与未微囊化胰岛素分泌无显著差异 ,微囊能够保护胰岛免受冻伤 。The microencapsulation of Sprague-Dawloy rat pancrea tic islets was carried out. The loss of pancrestic islets and the insulin excret ion function of the microencapsuled and nonmicroencapsuled samples after cryopre servation was compared. The loss of microencapsuled islets was only 1/2 of that of the nonmicroencapsuled islets. There was no marked difference in insulin excr etion between the two kinds of islets. Microencapsulation could reduce the loss of islets under cryopreservation.

关 键 词：微囊化 胰岛细胞 冷冻保存 大鼠 胰岛移植 

分 类 号：R657.5[医药卫生—外科学] R318.52[医药卫生—临床医学]