慢性肝病患者血清sICAM-1与TGF-β1水平及临床意义  

Study on relationship among sICAM-1、KTGF-β1 and cellular factor level change in sera of the patients with chronic hepatic disease and clinical significance

作　　者：李东复[1] 太京华[1] 潘留兰[1] 孟宪明[1] 金珍婧[1] 宋春莉[2] 

机构地区：[1]吉林大学第二医院消化内科,长春130041 [2]吉林大学第二医院心血管内科,长春130041

出　　处：《中国免疫学杂志》2001年第12期673-675,共3页Chinese Journal of Immunology

摘　　要：目的：为探讨慢性肝病患者血清可溶性粘附分子（sICAM-1）、转化生长因子β1（tgf-β1）水平与病毒复制及临床关系。方法：采用ELISA法对慢性乙型肝炎病毒性肝病患者血清sICAM－1、TGF-β1与炎症相关性细胞因子白细胞介素-l（IL-1）、白细胞介素-8（IL-8）及肿瘤坏死因子（TNFa）水平进行了平行测定。结果：慢性肝病患者血清sICAM－1、TGF-β1、IL-1、IL-8及TNFa水平明显高于健康对照组；慢性乙型肝炎 HBV－DNA和 HBeAg阳性患者明显高于 HBV-DNA或 HBeAg阴性患者，且与血清总胆红素含量呈正相关。结论：sICAM－l、TGF-β1及炎症相关性细胞因子水平与慢性肝病患者病情及携带HBV的活跃程度相关。Abstract Objective: To observe relationship among sICAM-1、TGF-β1, and cellular factor level changes in the sera of patients with chronic viral hepatic disease, viral replication and clinical significance.Methods;The sICAM-1 .TGF-β1, ,IL-1,IL-8 and TNFa level changes in the sera of patients with chronic hepatitis B(CH), chronic severe hepatitis B(CSH) and hepato-cirrhosis(HC) were detected by FJ-ISA. Re-sults: The sICAM-1, IL-1, IL-8 and TNFa levels in sera of patients with chronic viral hepatic disease were significantly higher than those of healthy group( P < 0.01) .The bilirubin level in the sera of patients with chronic viral hepatic disease of different clinical types had a parallel relationship with sICAM-1 and cytokine activities. The sICAM-1 level in the sera of HBV-DNA of HBeAg positive patients was significantly higher than those of negative patients( P <0.05).Conclusion:The level of sICAM-l.TGF-β1, and activities of cytokine IL-1,IL-8 and TNFa as also as the bilibrubin level in the sera of patients can reflect the necrosis degree of hepatocytes and the sICAM-1 level and activities of IL-1, IL-8 and TNFa were related to state of HBV carrier of the active degree of HBV in patients with hepatic diseaes

关 键 词：慢性肝病 细胞间粘附分子-1 细胞因子 ICAM-1 TGF-Β1 

分 类 号：R575[医药卫生—消化系统]