实验性肝细胞癌T_1WI成像与铁含量的关系  

MR Imaging of Hepatocellular Carcinoma in Rats: Correlation of Metal Iron Content and Signal Intensity

作　　者：陈伟[1] 巫北海[1] 丁仕仪[1] 梁智勇[1] 张绍祥[2] 

机构地区：[1]重庆市第三军医大学西南医院放射科,400038 [2]重庆市第三军医大学西南医院病理科,400038

出　　处：《中国医学影像学杂志》2001年第6期442-446,共5页Chinese Journal of Medical Imaging

摘　　要：目的 :探讨铁含量对肝细胞癌T1WI信号的影响。材料和方法 :用 0 2 %DEN (Sigma产品 )灌喂Wistar大鼠 80只 ,诱癌成功后行常规SE序列T1WI、T2 WI ,对照组 2 0只不灌喂DEN ,余同实验组。扫描后处死动物取肝组织与肝癌组织作HE、普鲁士蓝染色 ,并测定组织内水、铁含量。结果 :肝癌组织与癌周肝组织含水量无差异 ,肝癌组织中铁含量低于癌周肝组织 ,但在呈低信号的肝癌内含铁血黄素含量明显高于呈其它信号强度类型的肝组织。结论 :水含量不是影响肝癌MR表现的主要因素 ,含铁血黄素是导致肝癌T1WI呈低信号的因素之一。Purpose: To investigate the relationship between the content of iron and the signal pattern on MR images in hepatocellular carcinoma (HCC). Materials and Methods: Wistar rats (n=80) were examined on MR SE T 1 weighted and T 2 weighted after success of experimental hepatocellular carcinoma induced by 0.2% diethylnitrosamine. After MR examination, rats were killed and the tissues of HCCs identified by pathology, the quantities of water and iron determined. Results: there had no significant difference between HCCs and surrounding hepatic parenchyma of water content, the content of iron in HCCs average lower than surrounding parenchyma but the content of hemosiderin in HCCs with hypointense signal was higher than other pattern. Conclusion: The water content is not the primary factor for HCCs MR apperance, hemosiderin prolongs the T 1 value of HCCs on SE T 1 weighted.

关 键 词：肝细胞癌 铁含量 NMR 成像 

分 类 号：R730.44[医药卫生—肿瘤] R735.7[医药卫生—临床医学]