幽门螺杆菌感染与肝硬化关系的研究  

RELATION BETWEEN H.PYLORI INFECTION AND HEPATOCIRRHOSIS

作　　者：李森林[1] 杜玉兰[1] 付博[1] 谢佳平[1] 

机构地区：[1]聊城市人民医院消化内科,聊城市252000

出　　处：《滨州医学院学报》2001年第6期552-554,共3页Journal of Binzhou Medical University

摘　　要：目的 :研究肝硬化患者的幽门螺杆菌 ( HP)感染状况及其对肝性脑病和上消化道出血的影响。方法 :用尿素酶快速染色和瑞—姬染色确定 HP的感染 ,分析肝硬化与十二指肠疾病患者 HP感染率的差异 ;HP感染对肝硬化患者血氨浓度的影响 ;随访 HP阳性与阴性肝硬化患者肝性脑病的发生率 ;观察肝硬化并上消化道出血与非出血患者间 HP感染的差异。结果 :肝硬化与胃十二指肠疾病患者 HP感染无明显差异 ;HP感染能使肝硬化患者血氨浓度增加 ,从而使肝性脑病发生率增高 ;肝硬化并出血与非出血组 HP感染无明显差异。结论 :肝硬化患者的 HP感染无特异性 ;HP感染能促使肝性脑病的发生 ;HP感染在肝硬化并上消化道出血中未起主要作用。Objective:To study the status of H.pylori infection and its effect on hepatic encephalopathy (HE) and upper gastrointestinal hemorrhage (UGH) in patients with hepatocirrhosis.Methods:H.pylori infection was determined by rapid urease test and R J staining so as to analyze the difference of H.pylori infection between patients with hepatocirrhosis and ones with duodenal diseases and the effect of HP infection on the concentration of blood ammonia in patients with hepatocirrhosis,to estimate the incidence of HE in patients with and without HP infection,and to observe the difference of HP infection between hepatocirrhotic patients with and without hemorrhage of upper digestive tract.Results:The H.pylori infection had no obvious difference between hepatocirrhosis and gastric duodenal diseases,it could increase the blood ammonia level and the incidence of HE in patients with hepatocirrhosis.The H.pylori infective rate had no disparity in UGT and non UGT patients.Conclusion:The infection of H.pylori had no peculiar feature in hepatocirrhotic patients,it could accelerate occurrence of HE and was not main factor of UGH in cirrhotic patients.

关 键 词：幽门螺杆菌 肝硬化 血氨 相关性 

分 类 号：R575.2[医药卫生—消化系统] R378.99[医药卫生—内科学]