食道癌患者T细胞亚群、SIL-2R和TNF水平与细胞免疫状态  

T cell Subgroup, SIL-2R and TNF with Body Immune Status in Esop hageal Cancer Cases

作　　者：王虹玲[1] 钟本土[1] 陈旭峰[2] 戴惠芳[2] 

机构地区：[1]杭州医学高等专科学校,杭州310012 [2]浙江省肿瘤医院

出　　处：《浙江中西医结合杂志》2001年第11期678-679,684,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的 :通过检测食道癌患者外周血 T细胞亚群、可溶性白介素 2受体 (s IL- 2 R)和肿瘤坏死因子 (TNF)水平 ,探讨食道癌的发生发展与机体免疫状态的关系。方法 :采用 APAAP桥联免疫法检测 T细胞亚群 ,双抗夹心法定量检测 s IL- 2 R,细胞毒试验计数 TNF活性。结果 :食道癌患者 CD4细胞下降(43.6± 8.8) ,CD8细胞增加 (37.9± 6 .9) ,CD4/ CD8比值下降 (1.2 2± 0 .5 1)。s IL- 2 R水平升高 (792 .4±194 .9× 10 3 U/ L) ,TNF升高 (6 6 .1± 76 .6 U/ ml)。以上结果与对照比较均有显著性差异 (P<0 .0 1)。结论 :食道癌患者的细胞免疫状态存在明显异常 ,并与肿瘤的发生、进展和预后有关。To e xp lore the development of esophageal cancer with its relationship to the body immu ne status by detecting T cell subgroup, SIL-2R and TNF. Methods: T cell subgroup was detected with APAAP while SIL 2R was detected with ELISA . TNF was detected by cell toxicology. Results: CD4 was reduced in esophageal case while CD8 was increased. CD4/CD8 ratio was 1.22+0.51. SIL 2R and TNF were raised. There existed differences when compared with the control. Conclusion: The immune status in cancer cases was not normal and related to the development, progress and prognosis of the cancer cases.

关 键 词：T细胞亚群 SIL-2R TNF 食道癌 细胞免疫 

分 类 号：R735.1[医药卫生—肿瘤]