维生素D受体基因型与骨密度  

The relationship between vitamin D receptor gene polymorphisms and bone mineral density

作　　者：陈训华[1] 杨淑芹[1] 梁雅香[1] 张万强[1] 

机构地区：[1]中国中医研究院骨伤科研究所,北京100700

出　　处：《中国骨伤》2001年第9期531-532,共2页China Journal of Orthopaedics and Traumatology

基　　金：国家中医药管理局科研基金资助项目 (972 1 0 7)

摘　　要：目的　考察维生素D受体 (VDR)基因多态性在我国汉族人群中的分布频率 ,分析VDR基因型与骨密度的关系。方法　采用聚合酶链反应和限制性酶切技术检测 10 0例绝经前健康妇女VDR基因多态性。应用双能X线骨密度仪检测受试者腰椎及髋部骨密度。结果　VDR基因型分布频率为BB型 4 0 % ,Bb型 10 0 % ,bb型 86 0 % ;而三种基因型受试者髋部及腰椎骨密度均表现出Bb >bb>BB ,经F检验腰椎骨密度 3基因型比较 ,P <0 0 5 ,具有显著差异。结论　绝经前妇女VDR基因型分布频率与西方及国内的一些报道不尽相同 ,且骨密度显示出Bb >bb >BB 。Objective To study the frequency distribution of vitamin D receptor(VDR) gene polymorphisms in Chinese and to evaluate the relationship between VDR gene polymorphisms and bone mineral density(BMD)Methods VDR gene polymorphisms of 100 healthy pre-menopausal women was detected by using polymerase chain reaction(PCR) and restrictive analysis methods.The BMD values in lumbar vertebrae and hip of the women were measured by using dual energy X-ray absorptiometry(DEXA).Results The frequency distribution of VDR genotype was bb86 0%,Bb10 0% and BB4 0%.The BMD values in hip and lumbar vertebrae of the women with 3 type of gene were Bb>bb>BB(P<0 05).Conclusion In this study,the frequency distribution of VDR genotype in pre-memopausal women is sharply different from that of reports in western countries,as well as in Chinese.The BMD of Bb>bb>BB is also apart from other study results.

关 键 词：骨密度 基因型 骨质疏松 腰椎 髋 维生素D受体 基因多态性 

分 类 号：R681[医药卫生—骨科学] R336[医药卫生—外科学]