抗郑氏植物蛋白兔血清抑制小鼠体内肿瘤生长的初步研究  

Preliminary study on inhibition to mouse tumor growth in vivo of rabbit serum against Zheng′s plant protein

作　　者：邹岳奇[1] 郑振海 刘玉翠[1] 辛春艳[1] 吴萌[1] 

机构地区：[1]河北省科学院生物研究所细胞研究室,石家庄050081 [2]河北灵寿郑氏癌症研究所,河北灵寿050500

出　　处：《河北省科学院学报》2001年第4期238-240,共3页Journal of The Hebei Academy of Sciences

摘　　要：郑氏植物蛋白系从某种低等植物提取的一种糖蛋白。已有的实验结果提示郑氏植物蛋白具有肿瘤抗原活性。笔者对抗郑氏植物蛋白兔血清小鼠体内抗肿瘤作用进行了实验 ,结果表明 ,注射抗郑氏植物蛋白兔血清的试验组小鼠的实体瘤均重分别仅为生理盐水和正常兔血清两个对照组小鼠瘤块的 5 3.1%和 5 6 .5 % ,该抗血清对小鼠体内Sp2 / 0实体瘤的生长具有明显的抑制作用。Zheng's Plant Protein (ZPP) is a glycoprotein extracted from a lower plant. The results of some other experiments revealedthat ZPP is of the tumor antigen-like activity. The experiment of antitumor effect in vivo of rabbit-anti-ZPP serum was conducted and result showed that average tumor weight of test mice injected rabbit-anti-ZPP serum is less than both of control mice injected normal rabbit antiserum and normal saline respectively. It hinted that ZPP has important potential value in tumor diagnosing ,treating and tumor vaccine developing.

关 键 词：郑氏植物蛋白 抗血清 肿瘤免疫 抗肿瘤作用 肿瘤抑制 糖蛋白 小鼠 

分 类 号：R73－3[医药卫生—肿瘤]