EGFR及其配体EGF与甲状腺乳头状癌淋巴转移的关系研究  

The relationship between expression of EGFR &EGF and lymphatic metastasis in papillary thyroid carcinoma

作　　者：陶英杰[1] 黄宗堂[1] 刘经组[1] 

机构地区：[1]天津市肿瘤医院头颈科,天津300060

出　　处：《陕西肿瘤医学》2001年第1期14-16,63,共4页ShanXi Oncology Medicine

摘　　要：目的　研究EGFR及其配体EGF与甲状腺乳头状癌淋巴结转移的关系。方法　本实验采用免疫组化S -P法 ,检测了 2 5 1例甲状腺乳头状癌表皮生长因子受体 (EGFR) ,分析了受体表达情况与淋巴转移间的关系。并检测了 5 3例甲状腺乳头状癌患者血清及尿液中表皮生长因子 (EGF)的水平。结果　在甲状腺乳头状癌中 ,EGFR出现高水平表达 ,阳性率为 6 6 9% ,明显高于对照组。不同病理分型间 ,阳性率有所不同。包膜内型、腺内型和腺外型阳性率分别为 2 9 4%、73 9%和 71 3% ,其差别有统计学意义。当出现淋巴结转移时 ,EGFR阳性率升高。N0 转移组及N1组EGFR阳性率为 88 7% ,91 0 %明显高于N0 无转移组 (19 5 % ) ,有显著性差异。经相对危险度计算和线性趋势分析表明 ,随EGFR染色强度升高 ,转移风险升高 ,二者间呈线性关系。甲状腺乳头状癌患者血清及尿液中存在着高水平的EGF。甲状腺乳头状癌患者血清EGF水平为 1 6 8± 5 6 μg/L ,尿液中为 37 2± 10 8μg/L ,均高于甲状腺腺瘤组和正常对照组。提示EGF与肿瘤的发生有密切关系。结论　在N0 期甲状腺乳头状癌病例中 ,EGFR阳性应高度考虑颈淋巴结转移 ,从而为临床选择治疗方案提供参考。Objective To study the relationship between expression of EGFR and lymphatic metastasis in Papillary thyroid carcinoma.Methods We retrospectively studied 251 cases of papillary thyroid carcinoma EGFR were measured by an immuno-histochemical assay.And EGF level of serum and urine were detected by immunoradiometric assay in 53 cases of papillary thyrlid carcinoma.Results 66 9% cases present over-expression of EGFR.It's higher than that of control group(p<0 01).And expression of EGFR were increased in patients with lymphatic metastases.in N 0 non-metastasis group,the positive rate was lower than that of N 0metastasis and N 1group (p<0 01).O.R showed a significant association between the risk of metastasis and expression of EGFR.Comparing with control group,patients had higher level of EGF in both serum and urine.It indicated that EGF had association with carcinogenesis.Conclusion In N 0 papillary thyroid carcinoma patients,it would be the high-risk group of lymphatic metastasis that had high expression of EGFR.

关 键 词：甲状腺乳头状癌 表皮生长因子受体 淋巴结转移 表皮生长因子 免疫组化染色S-P法 

分 类 号：R736.1[医药卫生—肿瘤]