肝硬化大鼠及其全胃肠外营养时脂代谢的变化  

Changes of Lipid Metabolism in the Cirrhotic Rats and with TPN

作　　者：罗时敏[1] 厉鼎琦[1] 

机构地区：[1]江西省人民医院普外科,江西南昌330006

出　　处：《江西医学院学报》2001年第3期28-29,共2页Acta Academiae Medicinae Jiangxi

摘　　要：目的 :观察肝硬化大鼠及其全胃肠外营养时脂代谢的变化。方法 :Wistar大鼠分为 3组 :正常组 8只 ,肝硬化对照组 6只 ,肝硬化TPN组 7只。TPN进行 7d。测定血脂水平和肝脂含量。结果 :肝硬化大鼠血清TG和CHO水平均有不同程度的升高 ,肝TG含量明显升高 (P <0 .0 5 )。肝硬化TPN时 ,血清TG水平、肝TG、CHO含量进一步升高 (P <0 .0 5 )。结论Objective: To observe the changes of lipid metabolism in the cirrhotic rats and with total parenteral nutrition (TPN). Methods: 21 rats were divided into 3 groups: control group ( n =8), cirrhosis control group ( n =6) and cirrhosis with TPN group ( n =7). TPN lasted for 7 days. The levels of lipid in serum and liver were measured. Results: The levels of TG and CHO in serum, TG in liver were increased significantly in cirrhotic rats ( P &lt;0.05). The levels of TG in serum, TG and CHO in liver were further increased in cirrhosis with TPN group ( P &lt;0.05). Conclusion: The changes of lipid metabolism should be considered while TPN is administrated in cirrhosis.

关 键 词：肝硬化 全胃肠外营养 动物实验 脂代谢紊乱 

分 类 号：R575.2[医药卫生—消化系统] R459.3[医药卫生—内科学]