人参二醇皂甙对小鼠急性脑缺血损伤的保护作用  

Protective effects of panaxadiol saponin on acute cerebral ischemia injury in mice

作　　者：王国贤[1] 肖志洁[1] 宗瑞义[2] 

机构地区：[1]锦州医学院药理教研室,辽宁锦州121001 [2]白求恩医科大学药理教研室,吉林长春130021

出　　处：《锦州医学院学报》2001年第6期5-7,共3页Journal of Jinzhou Medical College

摘　　要：目的　探讨人参二醇皂甙 (PDS)对小鼠急性脑缺血损伤的影响。方法　部分结扎带迷走神经的颈总动脉制备急性脑缺血模型 ,记录 6h内的卒中指数 ,12h内的死亡率。于缺血 90min时断头取脑 ,测定脑组织中乳酸 (LA)、乳酸脱氢酶 (LDH)、丙二醛 (MDA)及超氧化物歧化酶 (SOD)含量。结果　PDS缺血前30minip能降低卒中指数 ,减少死亡率 ,PDS尚能降低缺血脑组织中LA和MDA含量 ,提高LDH和SOD活性。结论　PDS对小鼠急性脑缺血损伤具有保护作用 ,其作用机制与减轻组织酸中毒 。Objective To investigate the effects of panaxadiol saponin(PDS)on acute cerebral ischemia injury in mice.Methods Acute cerebral ischemia injury of mice was produced by partial ligation of bilateral common carotid arteries with vagi.The apoplectic index and mortality were recorded.At 90 min of cerebral ischemia cerebral hemispheres were taken out,the contents of lactic acid(LA),lactic dehydrogenase(LDH),malondiadehyde(MDA)and superoxide dismutase(SOD)in ischemic brain tissue were determined.Results PDS ip 30 min before ischemia can decrease the apoplectic index and mortality,and reduce the contents of LA and MDA,and increase the activities of LDH and SOD in brain tissue.Conclusion PDS has protective effects on acute cerebral ischemia injury of mice.The effective mechanism of PDS might relate to reducing acidosis and inhibiting lipid peroxidation.

关 键 词：人参二醇皂甙 脑缺血 乳酸 丙二醛 超氧化物歧化酶 

分 类 号：R285.5[医药卫生—中药学] R277.733.1[医药卫生—中医学]