阿苯达唑乳剂治疗肝囊型包虫病212例临床疗效观察  

Efficacy of Ablendazole Emulsion in Treatment of 212 Patients with Cystic Echinococcosis

作　　者：柴君杰[1] 孟贺巴特[1] 焦伟[1] 孙德玉[1] 梁斌[1] 石劲草[1] 付承[1] 李雄[1] 毛一丁[1] 王秀玲[1] 多力坤[1] 古丽拜尔[1] 王燕春[1] 高芳华[2] 肖树华[2] 

机构地区：[1]新疆地方病防治研究所 [2]中国预防医学科学院寄生虫病研究所,上海200025

出　　处：《中国寄生虫学与寄生虫病杂志》2001年第3期129-134,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家"九五"科技攻关项目 ( 96 -90 6 -0 4-0 9)&&

摘　　要：目的　验证新剂型阿苯达唑乳剂对肝囊型包虫病患者的临床疗效。　方法　对 2 12例肝囊型包虫病患者用阿苯达唑 10 m g/ (kg· d)和 12 .5 mg/ (kg· d)两种剂量进行治疗。服药 3个月复查 1次为 1个疗程 ,各疗程之间不间断连续用药。以 B超影像特征为主判定疗效 ,观察不同疗程的效果。以停药时的检查结果为近期疗效。停药后随访 1～ 4年的结果为远期疗效。　结果　两个剂量组共 2 12例患者的平均近期疗效 :治愈率为74.5 % ,有效率为 99.1% ,无效率为 0 .9%。平均远期疗效 :治愈率为 83.1% ,有效率为 89.3% ,无效率为 0 .6 % ,复发率为 10 .2 %。以 12 .5 mg/ (kg· d)连续治疗 9个月的疗效较好。复发病例再治疗的效果良好。　结论　阿苯达唑乳剂对肝囊型包虫病的临床疗效超过当前包虫病药物治疗的最好水平 ,疗效稳定可靠 ,不良反应轻微 ,可成为治疗包虫病的首选药物。Objective To verify the efficacy of abendazole emulsion, a new formulation of abendazole, in treatment of human cystic echinococcosis. Methods 212 patients with liver cystic echinococcosis were treated orally with albendazole emulsion at a daily dose of 10 mg/kg or 12\^5 mg/kg for 3 to 12 months or over one year. The therapeutic efficacy was mainly \{evaluated\} by image feature examined with B utrasound examination, a short-term efficacy at the completion of treatment and a long-term efficacy followed-up for 1-4 years. Results In 212 patients treated with albendazole emulsion at a daily dose of 10 mg/kg and 12\^5 mg/kg, the average cure rate, improved rate and the rate of no avail were 74\^5%, 99\^1% and 0\^9% respectively after termination of the treatment, and the average long-term rates were 83\^1%, 89\^3% and 0\^6% respectively. Recurrence occurred in 18 patients(10\^2%). The results indicated that the best efficacy was seen in patients treated with albendazole 12\^5 mg/kg daily for 9 months. Better response was also found when the recurrent patients were re-treated with albendazole. Conclusion The efficacy of albendazole emulsion on patients with liver cystic echinococcosis is much better than that of albendazole tablet or capsule and mebendazole. Meanwhile, the efficacy of albendazole emulsion is stable with less adverse effects. The results suggest that albendazole emulsion could be the drug of choice for treatment of cystic hydatid disease.

关 键 词：囊型包虫病 囊型棘球蚴病 细粒棘粒绦虫 阿苯达唑乳剂 临床疗效 治疗 

分 类 号：R532.320.5[医药卫生—内科学]