慢性胃炎胃黏膜细胞凋亡的检测及意义  

EPITHELIAL CELL APOPTOSIS IN CHRONIC GASTRITIS

作　　者：郝志明[1] 苌新明[1] 吴玉娥[1] 周秦蜀[1] 罗金燕[2] 

机构地区：[1]西安交通大学第一医院,西安710061 [2]西安交通大学第二医院

出　　处：《中国现代医学杂志》2002年第4期14-15,共2页China Journal of Modern Medicine

摘　　要：目的 :检测慢性胃炎各阶段黏膜细胞凋亡状况及探讨其意义。方法 :用TUNEL法检测 6例正常胃黏膜、5 4例慢性浅表性胃炎 (CSG)及 2 8例慢性萎缩性胃炎 (CAG)患者胃黏膜上皮细胞凋亡状况。结果 :凋亡指数(AI)CSG >CAG >正常胃黏膜 (P <0 .0 5 ) ,而且炎症黏膜凋亡细胞分布与正常有所不同 ;在CAG ,AI在肠化区 <非肠化区。结论 :细胞凋亡在CAG黏膜萎缩及肠化发生中起重要作用。CAG黏膜AI下降可能与胃癌发生有关。Objective:To investigate the significance of antral epithelial cell apoptosis in each stage of chronic gastritis.Method:Apoptotic cells were detected by TUNEL in the gastric antral mucosa from 6 normal controls,54 patients with chronic superficial gastritis (CSG) and 28 patients with chronic atrophic gastritis (CAG).Results:Apoptosis index (AI) in CSG was significantly higher than that in CAG (16.5±4.1 vs 11.3±3.9, P <0.01) and in CAG was significntly higher than that in normal controls (11.3±3.9 vs 3.3±2.8, P <0.01).Furthermore,the distribution of apoptotic cells in chronic gastritis was different from that in normal controls.AI in non_metaplastic areas was significantly higher than that in intestinal metaplastic areas of CAG.Conclusions:Apoptosis plays an important role in the development of CAG.The decrease of AI in atrophic mucosa may contribute to the development of gastric carcinoma.

关 键 词：细胞凋亡 慢性胃炎 胃黏膜细胞 

分 类 号：R573.3[医药卫生—消化系统]