癌胚抗原检测预测胃肠道肿瘤转移的前瞻性研究  

A prospective study on metastasis from gastrointestinal carcinoma predicted by detection of CEA in peripheral and portal blood

作　　者：利军[1] 郭强[1] 孙劲松[1] 孙功平[1] 

机构地区：[1]巢湖市第一人民医院外一科,238000

出　　处：《安徽医学》2002年第1期8-9,共2页Anhui Medical Journal

摘　　要：目的　旨在探讨外周血与门脉血癌胚抗原 (CEA)值的差异并用于前瞻性预测胃肠道肿瘤术后转移。方法　采用单克隆抗体放射免疫显影法 ,对 64例胃肠道肿瘤患者在手术过程中抽取外周与门脉血作CEA检测。结果　64例患者中 ,38例患者外周血CEA值低于门脉血 (P <0 0 5) ,2 6例患者外周血CEA值高于门脉血 (P <0 0 5)。全部患者术后随访 4个月～ 2年 ,外周血CEA值低于门脉血的 38例患者中 ,9例发生肿瘤转移 ,转移率 2 3 6 % (9/ 38)。外周血CEA值高于门脉血的 2 6例患者中 ,两年内共有 1 7例发生肿瘤转移 ,转移率 65 3 % (1 7/ 2 6)。两者差异有非常显著性意义 (P >0 0 1 )。结论　外周血CEA值高于门脉血的胃肠道肿瘤患者术后肿瘤转移率高 ,术中行两个系统血样CEA检测结果能前瞻性预测胃肠道肿瘤术后转移的高危患者 ,对临床上积极采取治疗措施有明显的指导价值。Objective To explore the difference between CEA in peripheral and portal blood and to predict metastasis from primary gastrointestinal carcinoma. Methods CEA in peripheral and portal blood of 64 patients with gastrointestinal carcinoma was detected by monoclonal antibody radioimmunoimaging.Results CEA in peripheral blood of 38 patients with gastrointestinal carcinoma was much lower than those in portal blood (P<0 05),and CEA in peripheral blood of 26 patients much higher than those in portal blood (P<0 05).All patients were followed up from 4 months to 2 years,9 cases metastasis were found in 38 patients, which CEA in peripheral blood was lower than those in portal blood,the currence rate of metastasis was 23 6%,and 17 cases metastasis were found in 26 patients, which CEA in perihperal blood was higher than those in portal blood, the rate of metastasis was 65.3%,the difference were much significant (P<0.01). Conclusions The rate of postoperative metastasis is higher in patients with gastrointestinal carcinoma, which CEA in peripheral blood is higher than those in portal blood.Detection of CEA is helpful to prospectively predict neoplasm metastasis of gastrointestinal carcinoma in the early stage of postoperation.

关 键 词：胃肠道肿瘤 肿瘤转移 癌胚抗原 门静脉血 前瞻性预测 

分 类 号：R735[医药卫生—肿瘤]