大鼠蓝斑内注入谷氨酸钠的心血管效应及其中枢机制  

CENTRAL NEURAL MECHANISM UNDERLYING PRESSOR RESPONSE TO EXCITATION OF LOCUS COERULEUS IN RATS

作　　者：邹长江[1] 周旭[1] 顾蕴辉[1] 

机构地区：[1]北京医科大学生理教研室,北京100083

出　　处：《生理学报》1991年第6期556-564,共9页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：本工作在乌拉坦麻醉、箭毒化、人工呼吸的大鼠观察到:(1)将 L-谷氨酸钠(Glu)微量注入蓝斑(LC)引起血压升高,心率无明显变化;注入 LC 邻近区引起血压降低、心率减慢。(2)在下丘脑的室旁核尾侧断脑可衰减 LC 加压效应,而室旁核头侧断脑对 LC 加压反应无明显影响,双侧延髓头端腹外侧区(RVL)内分别注射酚妥拉明、心得安、阿托品均使兴奋 LC 引起的加压效应衰减;提示蓝斑加压效应由室旁核和 RVL(及其内的α-、β-肾上腺素能受体,M-胆碱能受体)介导。Experiments were done on urethane anesthetized,tubocurarine immobilizedand artificially ventilated rats and the following results were observed:(1)Injec-tion of sodium L-glutamate(Glu)into locus coeruleus(LC)could evoke a pressorreponse,but heart rate was not significantly affected;while depressor and bra-dycardia effects were observed when injecting into closely adjacent areas.(2)The LC-pressor response decreased after a brain transection caudal to nucleusparaventricularis was made but remained unchanged if the transection wasrostral to the nucleus;The LC-pressor response could also be attenuated by pre-injection of phentolamine,propranolol or atropine respectively into the rostralventrolateral medulla(RVL).The above results suggest that LC-pres sor responseis not only mediated by RVL,but also by nucleus paraventricularis.

关 键 词：蓝斑 谷氨酸钠 心血管效应 下丘脑 

分 类 号：R331.36[医药卫生—人体生理学]