凋亡抑制基因Bcl-2和增殖细胞核抗原在乳腺导管浸润癌中的表达及意义  

Expressions of Bcl-2 and PCNA in invasive ductal carcinoma of breast and their clinical significance

作　　者：王丽萍[1] 陈东[2] 陈爱军[2] 王晓明[2] 张元德[1] 张俊格[1] 张玫琦[2] 苏学志[3] 李雪梅[3] 

机构地区：[1]吉林大学第一医院病理科,吉林,长春,130021 [2]吉林大学基础医学院组胚教研室 [3]吉林大学第一医院病理科,吉林,长春,130021吉林大学基础医学院组胚教研室

出　　处：《吉林大学学报（医学版）》2002年第1期43-45,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科委基金资助项目 (970 5 6 5 - 4 )

摘　　要：目的 :探讨凋亡抑制基因 Bcl- 2和增殖细胞核抗原 ( PCNA)在乳腺导管浸润癌中的表达及与各临床参数的关系。方法 :免疫组织化学染色法对 35例乳腺导管浸润癌患者进行检测。结果 :Bcl- 2和 PCNA蛋白表达均为 68.6% ;Bcl- 2表达与癌组织分级及有无淋巴结转移呈负相关( P<0 .0 1 ) ,与雌激素 ( ER)水平及 5年生存期呈正相关 ( P<0 .0 1 ) ,与肿物大小无关 ;PCNA表达与癌组织分级及肿物大小呈正相关 ( P<0 .0 5 ) ,与 ER水平及 5年生存期呈负相关 ( P<0 .0 5 ) ,与淋巴结有无转移无关 ;Bcl- 2与 PCNA表达呈负相关。结论 :Bcl- 2高表达、ER水平高、PCNA表达低者生存期长、预后好 ,Bcl- 2和Objective:To examine the expressions of apoptosis suppressor gene Bcl 2 and proliferating cell nuclear antigen (PCNA) in invasive ductal carcinoma of breast and their clinical significance. Methods:35 cases of paraffin embedded specimens of invasive ductal breast cercinoma were used for immunohistochemical study.Results:The positive rates of both Bcl 2 and PCNA expression were 68.6%.The expression rate of Bcl 2 was closely correlated with the level of estrogen receptor (ER) and the five year survival ( P <0.01,respectively) whereas the expression of Bcl 2 was not related to tumor size.The relationship between the expression of PCNA and histological grade or lymphnode metastases was negative correalted ( P <0.05).The expression of PCNA was closely correlated with tumor size and histological grade ( P <0.05),negative correlated with the age,the level of estrogenrceptor and the survival duration ( P <0.05),no related to lymph node netastases.Conclusion:The results suggest that either over expression of Bcl 2 and or low expression of PCNA predicts a good prognosis and long survial duration.

关 键 词：乳腺导管浸润癌 免疫组织化学 凋亡抑制基因 BCL-2 增殖细胞核抗原 

分 类 号：R737.9[医药卫生—肿瘤]