急性白血病伴CD_(56)阳性的临床意义  

CLINICAL SIGNIFICANCE OF ACUTE LEUKEMIA WITH CD_( 56) POSITIVE

作　　者：麻柔[1] 许勇钢[1] 胡晓梅[1] 杨经敏 刘锋[1] 杨晓红[1] 张姗姗[1] 胡乃平[1] 王忠芬[1] 杨柳[1] 刘驰[1] 杨留[1] 

机构地区：[1]中国中医研究院西苑医院全国中医血液病临床中心,北京100091

出　　处：《白血病．淋巴瘤》2001年第5期265-268,共4页Journal of Leukemia & Lymphoma

摘　　要：目的 :探讨 CD56在急性白血病中的表达及其临床意义。方法 :就近 2年来应用流式细胞仪检测了CD56的 92例急性白血患者中发现的 CD56阳性病例 ,分析细胞形态学、免疫表型和临床特点。结果 :92例急性白血病中 15例 (16 .3% )表达 CD56,其中 1例急性前髓系 /NK细胞白血病 (Myeloid/NK cell precursor acute leukem ia) ,1例原始 NK细胞白血病 (Blastic NK cell leukemia) ,1例 NK样 T细胞淋巴瘤 /白血病 (NK- like T- cell lymphoma/leukemia) ,12例急性髓细胞白血病伴 NK细胞抗原表达或急性髓系 /NK细胞白血病。结论 :伴 CD56阳性急性白血病 ,其细胞形态学、免疫表型及临床表现各有特点 ,见于 M2 、M5、L2 ,髓外浸润多见 ,多预后不良。Objective:To investigate the expression of CD 56 on acute leukemia and its clinical manifestation.Methods:Immunophenotype of 92 cases with acute leukemia was measured by flow cytometry,the morphology,immunophenotype and clinic of CD 56 positive patients was analyzed.Results:15/92(16.3%)cases with acute leukemia expressed CD 56 ,one patient has been tesified to be myeloid/NK cell precursor acute leukemia,one patient has been testified to be blastic NK cell leukemia,one patient has been testified to be NK like T cell lymphoma/leukemia,12 patients are like to be acute myeloid leukemia with NK antigen expression or myeloid/NK cell acute leukemia.Conclusion:CD 56 positive acute leukemia is heterogeneous,its morphology,immunophenotype and clinical manifestation is different,they were associated with M 2?M 5?L 2;they had more infiltration out marrow and prognosis was poor.

关 键 词：急性白血病 CD56 流式细胞仪 预后 

分 类 号：R733.71[医药卫生—肿瘤]