喉全切除后造瘘口复发癌危险因素的多因素分析  

Mutivariate analysis of risk factors for stomal recurrence cancer after laryngectomy

作　　者：张仑[1] 刘静[1] 

机构地区：[1]天津医科大学附属肿瘤医院头颈外科,300060

出　　处：《耳鼻咽喉（头颈外科）》2001年第5期280-282,共3页Chinese Arch Otolaryngology-Head Neck Surg

摘　　要：目的：探讨全喉切除后造瘘口复发癌的有关危险因素。方法：１９７８～１９９８年我院收治４１１例喉全切除的喉癌患者，其中５８例造瘘口癌复发（１４．１％）。可能造成造瘘口的复发癌的危险因素通过ｃｏｘ模型分析。结果：声门下、跨声门侵犯和肿瘤Ｔ_３、Ｔ_４期与复发有关。结论：喉全切除后造瘘口复发癌是最严重的晚期并发症。其与声门下癌扩展以及原发癌喉外侵犯密切相关。Objective:To detect the risk factors of stomal recurrence cancer in patients with total laryngectomy. Methods:From 1978 to 1998,411 patients with laryngeal carcinoma were treated by total laryngectomy. Among 411 cases (317 males and 94 females,ranging in age from 35 to 79 years old, stage T_2, 93,T_3, 237,T_481 ), 58 cases were stomal recurrence cancer (14. 1 % ) after two-year total laryngectomy. The risk factors of stomal recurrence cancer were analyzed with cox model. Results:The rate of stomal recurrence cancer was 24. 3% (9/37) in subglottic cancer, 33. 9% (19/56) in transglottic cancer, 13. 5 % (32/237)in stage T_3, and 28. 4 % (23/81 )in stage T_4. Above 4 factors were showed correlation with the stomal recurrence cancer. Conclusion:The stomal recurrence cancer after total laryngectomy is the most devastating late complicansion. Its development is closely associated with subglottic extension,extralaryngeal spread of the primary tumor(stage T_4).

关 键 词：喉肿瘤 喉切除术 复发癌 危险因素 

分 类 号：R739.65[医药卫生—肿瘤]