肝硬化患者脂质代谢紊乱及其临床意义  

The Disorder of Blood Lipid of Patients with Liver Cirrhosis and its Clinic Significance

作　　者：胡阳黔[1,2] 王子强[1,2] 徐章[1,2] 黄晓东[1,2] 姜红梅[1,2] 

机构地区：[1]东风公司总医院消化科 [2]湖北郧阳医学院东风临床医院,十堰442008

出　　处：《临床消化病杂志》2001年第5期214-216,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的 :了解肝硬化 (LC)患者的血脂质变化及其临床意义。方法 :选择 89例LC患者及 2 0例对照者清晨空腹采静脉血检测TC、TG、HDL C、LDL C、apoA、apoB、Lpa及肝功能 ,比较各组血脂水平的差异性并将血脂质与肝功能进行相关性检验。结果 :LC患者各项血脂质除TG外普遍低于对照组 ,其中LDL C、apoA、Lpa具显著性意义 (P <0 0 5～ 0 0 0 0 1) ,部分脂质LC各亚组间亦存在显著性差异 ,其下降程度与肝损害程度平行。血脂质与肝功能相关性检验显示TC、LDL C、apoA、Lpa与TBiL呈负相关 (P <0 0 5～ 0 0 0 0 1) ,TG、apoB与ALT呈正相关 (P <0 0 5 ) ,TG、apoB与AST呈正相关 (P <0 0 5～ 0 0 0 1) ,apoA、Lpa与AST呈负相关 (P <0 0 1) ,TC、HDL C、LDL C、apoA、apoB、Lpa与Alb呈正相关 (P <0 0 1～ 0 0 0 1)。结论 :LC患者存在多项血脂质不同程度下降且与TBiL、ALT、AST、Alb等常规肝功能试验有很好的相关性 ,因此可将血脂质的水平作为评价肝功能的一项参考指标。Purpose: To estimate the change of blood lipid of patients with liver cirrhosis(LC) and its clinic significance. Methods: Collect vein blood before breakfast of 89 patients with LC and 20 the control groups and examine their TC?TG?HDL C?LDL C?apo A?apo B?Lp a? liver function with different methods. Compare the difference of lipid of various groups. Test the correlation of blood lipid and liver function. Results: Blood lipid of patients with LC is lower than control group, except for TG. The difference of LDL C?apo A?Lp a is obvious(P<0 05～0 0001). The difference of subgroups of patients with LC is obvious. The decreased degree is parallel with the lesion of liver function. The correlation test shows that TC?LDL C?apo A?Lp a correlates with TBiL negatively(P<0 05～0 0001). TG?apo B correlates with ALT positively(P<0 05). TG?apo B correlates with AST positively(P<0 05～0 001), apo A?Lp a correlates with AST negatively(P<0 01), TC?HDL C?LDL C?apo A?apo B?Lp a correlates with Alb positively(P<0 01～0 001). Conclusion: Blood lipid of patients with LC decrease so or less and the decreased degree correlates with regular indicators well such as TBiL?ALT?AST?Alb. Threfore, blood lipid level can be used as a reference indicator of liver function.

关 键 词：肝硬化 血脂质 肝功能 

分 类 号：R575.2[医药卫生—消化系统]