胃癌病人血清IL-2R、IL-10、IL-12水平的变化  

Changes of Serum Soluble Interleukin-2 Receptor,Interleukin-10and Interleukin-12 in Patients with Gastric Cancer

作　　者：郭伟剑[1] 李兆东[1] 陈强[1] 郑磊贞[1] 沈伟[1] 蔡嵘[1] 顾文华[1] 庄军燕[1] 

机构地区：[1]上海第二医科大学新华医院肿瘤中心,上海200092

出　　处：《肿瘤学杂志》2001年第6期343-345,共3页Journal of Chinese Oncology

摘　　要：[目的]观察胃癌病人血清可溶性白介素2受体(sIL 2R)、白介素10(IL 10)、白介素12(IL 12)表达水平的变化。[方法]A组(正常对照组)12例 ,B组(胃癌带瘤组)22例 ,C组(胃癌术后半年内无复发组)20例 ,D组(胃癌术后半年以上无复发组)21例 ,ELISA法检测各组血清IL 2R、IL 10、IL 12水平。[结果]与A组相比 ,B组的IL 2R水平明显升高(P<0.005) ,B、C组的IL 12水平明显降低(P<0.005) ,与B组相比 ,D组的IL 2R水平明显降低(P<0.005) ,IL 12水平明显回升(P<0.05)。IL 12水平与IL 2R、IL 10水平无明显相关性。[结论]胃癌病人血清IL 2R水平升高 ,IL 12水平降低 ,根除肿瘤后IL 2R、ILTo observe the changes of serum interleukin 2 receptor (IL_2R),interleukin_10 (IL_10) and interleukin_12 (IL 12)in patients with gastric cancer.Patients were divided into four groups:group A(normal control,12 cases),group B(patients with gastric cancer burden,22 cases),group C(patients without recurrence within half a year after resection of gastric cancer,20 cases),group D(patients without recurrence beyond half a year after resection of gastric cancer,21 cases).Serum level of IL 2R,IL 10 and IL 12 were assayed by ELISA.Compared with group A,serum IL 2R in group B increased significantly (P<0.005),and IL 12 in group B and group C decreased significantly (P<0.005).Compared with group B,IL 2R in group D increased significantly (P<0.005),and IL 12 increased significantly(P<0.05).No obvious correlation between the level of IL 12 and IL 2R or IL 10 was found.[Conclusion]In patients with gastric cancer,serum IL 2R increased and IL 12 decreased.After tumor eradicated curative IL 2R and IL 12 will return to normal level gradually.

关 键 词：白细胞介素2受体 白细胞介素 IL-10 胃癌 

分 类 号：R735.203[医药卫生—肿瘤]