非小细胞肺癌术后放射治疗疗效影响因素  

The Effect of Postoperative Radiotherapy for Non-small Cell Lung Cancer

作　　者：程文芳[1] 钱飞宇[1] 李云英[1] 

机构地区：[1]福建省肿瘤医院,福建福州350014

出　　处：《肿瘤学杂志》2001年第6期359-360,共2页Journal of Chinese Oncology

摘　　要：[目的]分析非小细胞肺癌术后的放射治疗影响因素。[方法]对1989年4月～1996年7月收治的非小细胞肺癌术后214例 ,接受 60Co或8MVX线放疗 ,肿瘤量为40Gy～70Gy。用Cox单因素和多因素回归分析法分析影响术后放疗疗效的因素。[结果]3、5年生存率32.00 %、21.03% ;复发率42.00%、70.09%。鳞癌患者生存率高于腺癌者 (P<0.01) ,复发率则低于腺癌者 (P<0.05)。当T1～2 时N0～1 比N2～3 生存率高 (P<0.01) ,当T3～4 时 (P<0.05)。肿瘤有残留者生存率差于切缘阳性者和/或局部淋巴结阳性 ,且复发率高 (P<0.01)。照射剂量≥50Gy者生存率高于<50Gy者 ,而复发率低 (P<0.05)。性别、年龄、术后时间不影响预后。[结论]肺癌术后的放疗影响生存率 ,复发率的主要因素为病理类型、术后残留情况。To analysis the effect of radiotherapy in patients with non small cell lung cancer after operation .Two hundred anel fourteen patients with non_small cell lung cancer were treated in our hospital from April 1989 to July 1996.They had a radiotherapy with 8MV X line or 60Co whose tumor dose was 40Gy～70Gy.Cox regression model were used to analysis the factors which influence therapeutic effect in 214 patient.The survival rate of 3 and 5 years was 32.00% and 21.03% respectively.The recurrent rate of 3 and 5 years was 42.00% and 70.09% respectively.Patients with squamous cancer had a better survival rate(P<0.01)and less recurrent rate than patients with adenocarcinoma cancer (P<0.05).Better survival rate in patients with N0～1than those in patients with N2～ 3was found.Patients with residual tumor had a worse survival rate and less recurrence rate than those with positive wargin or with positive nodes (P<0.01).Patients who received radiotherapy with DT ≥50Gy had a better survival rate and less recurrent rate than those with DT<50Gy.Sex,age and postoperative time did not affect the prognosis.[Conclusions]Pathologic type,residual tumor,positive margin and the dose (P<0.05)of radiation are the affected factors to survival and recurrence in non small cell lung cancer.

关 键 词：非小细胞肺癌 放射疗法 外科学 预后 治疗 

分 类 号：R734.205[医药卫生—肿瘤]