重要的原料药——辅酶Q_(10)  

An Important Bulk Pharmaceutical: Coenzyme Q_10

作　　者：赵美法[1] 

机构地区：[1]青岛天元化工股份有限公司

出　　处：《精细与专用化学品》2001年第22期6-8,共3页Fine and Specialty Chemicals

摘　　要：辅酶Q10的合成方法有4种:生物提取法、微生物发酵法、半化学合成法、化学合成法,其中微生物发酵法是近几年国内外开发的热点,被认为是较有前途的合成工艺。日本是最主要的辅酶Q10生产国,据统计,全球90％的辅酶Q10来自日本,日清制粉和协和发酵工业公司是产量最高的两家公司。我国目前采用生物提取法生产辅酶Q10,总生产能力约为600kg/a,而2000年我国几个主要海关辅酶Q10的进口量就达14689kg,出口量为1278kg,市场缺口较大。我国茄呢醇生产能力接近100t/a(折百),应充分利用原料资源优势,攻克半合成法生产辅酶Q10的难关。There are four synthesis methods of coenzyme Q10 : bio-extraction, microbiological fermentation, semi-chemical synthesis and chemical synthesis. Among these, microbiological fermentation method is the hot spot of development at home and abroad and considered to be a synthesis process with broad prospects. Japan is the most important producer of coenzyme Q10. According to statistics, 90% coenzyme Q10 in the world is from Japan, Nissin Powder Mills Ltd. and Kyowa Hakko Kogyo Co. , Ltd. have the biggest output. In China, bio-extraction method is adopted for manufacturing coenzyme Q10, with total capacity of 600kg/a, however, the imports were 14689kg in 2000, exports were 1278kg, there was a bigger market gap. Because China' s solanesol capacity is bigger, the country should make the best use of raw material resource advantage, make breakthroughs in semi-synthesis method for manufacturing coenzyme Q10.

关 键 词：辅酶Q10 茄呢醇 半化学合成法 生物提取法 微生物发酵法 原料药 

分 类 号：TQ28[化学工程—有机化工]