肺癌患者血清CEA和CA242表达的临床意义  

CLINICAL SIGNIFICANCE OF SERUM CA242 AND CEA IN PATIENTS WITH PULMONARY CARCINOMA

作　　者：张洪福[1] 刘黎明[1] 尹秋伟[1] 

机构地区：[1]山东大学齐鲁医院胸外科

出　　处：《山东医科大学学报》2001年第6期537-538,541,共3页Acta Academiae Medicinae Shandong

摘　　要：目的 :探索肿瘤标记物CEA和CA2 4 2在肺癌诊断、预后及手术效果判断中的应用价值。方法 :用ELISA(酶联免疫吸附测定 )法分别检测肺癌患者、肺良性疾病患者手术前后及健康人血清中CEA和CA2 4 2表达的水平。结果 :①肺癌患者血清CEA和CA2 4 2水平明显高于肺良性疾病患者及健康对照组 ;②在肺癌组 ,血清CEA和CA2 4 2表达水平 ,Ⅲ期患者高于 0 +Ⅰ +Ⅱ期患者 ,腺癌患者高于鳞癌患者 ;③CEA和CA2 4 2联合检测可以提高肺癌诊断的阳性率 ;④肺癌患者切除术后血清CEA和CA2 4 2表达水平明显降低。结论 :①CA2 4 2与CEA相比是诊断肺癌更好的血清学指标 ,与TNM分期呈正相关 ;②两项指标与肺腺癌的关系最为密切 ;③两项指标联合检测明显优于单一的肿瘤标记物检测 ,可以提高肺癌诊断的阳性率 ;④术后CEA和CA2 4 2的血清浓度与术前相比明显降低 ,说明两者的表达与肿瘤负荷有关 ,并能提示手术效果及预后。Objective:To explore the clinical significance of CA242 and CEA in lung cancer diagnosis,prognosis and estimation of surgical effect.Methods:Using enzyme linded immunosorbent assay(ELISA),the serum levels of CEA and CA242 in patients with lung cancer,benign disease and in normal control were determinated respectively.Results:①Serum concentrations of CA242 and CEA were significantly higher in patients with lung cancer than in patients with benign disease and normal control;②Within patients with lung cancer,serum concentration of CA242 and CEA were higher in stage Ⅲ than in stagen Ⅰ and stage Ⅱ,and higher in adenocarcinoma than in squamous cancer;③The use of CEA and CA242 in combination increased the sensitivity of lung cancer diagnosis;④The preoperative and postoperative levels of serum CA242 and CEA were significantly different.Conclusion:①CA242 and CEA can be used in diagnosis of lung cancer,the expressions of two markers are positively correlated with P TNM stage;②The two tumor markers are best expressed in adenocarcinoma;③Combination of CA242 and CEA can increase sensitivity of measurement;④Postoperative serum concentrations of CEA and CA242 reduces obviously,this testifies that the expression of the two markers is correlated with tumor burden,so it can imply the surgical effect and prognosis.

关 键 词：肿瘤标记生物学 CA242 肺肿瘤 癌胚抗原 酶联免疫吸附测定 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]