放射性药物内照射治疗后肿瘤控制概率计算模型的研究  

Research on calculation modes of tumor control probability following internal radionuclide therapy

作　　者：鞠永健[1] 孙福印[1] 苑淑渝[1] 袁石林[1] 

机构地区：[1]中国医学科学院,中国协和医科大学放射医学研究所,天津300192

出　　处：《中华放射医学与防护杂志》2001年第5期367-370,共4页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金资助项目 ( 396 70 2 2 8);卫生部课题资助项目( 98 1 0 43)

摘　　要：目的　导出一个考虑剂量及生物学影响因素、能计算放射性药物内照射治疗后肿瘤控制概率 (TCP)的模型。方法　参考现有的放射治疗TCP模型 (模型 1和 2 )、细胞存活率模型 ,导出依赖于剂量、辐射敏感性、DNA单链断裂修复等因素的内照射治疗后的TCP计算模型 (模型 3) ,然后在同一治疗条件下以核素32 P为例 ,用模型 3和模型 1、2分别进行计算并对结果进行比较。结果　在假设的参数条件下 ,模型 3所算得的给定治疗活度时的可治疗的肿瘤半径范围最小且点源时与实验结果最接近、活度无穷大时其最大限度的治疗半径最小且点源时与核素的最大射程吻合 ,要比模型 1、2算得的结果更接近于实际情况。结论　模型 3比较全面地考虑了涉及的因素 ,可用于肿瘤的TCP值计算 。Objective\ To construct a calculation model of tumor control probability (TCP) with consider ation of the effect of dose and biological factors,It's expected that the result calculated by the model following internal radionuclide therapy would be appropriate to the actual value. Methods\ Referring to the TCP models of radiotherapy and the models of cell survival rate reported by other authors,a TCP model (model 3) following internal radionuclide therapy,which considered the effect factors of dose,repair of DNA single strand damage,radiosensitivity has been set up.Then using nuclide 32 P as an example,model 3 will be compared with the other two models (model l and 2) by calculation the TCP value under the same treatment conditions. Results\ Compared with model 1 and 2,the result calculated by model 3 shows that:1.With a certain treatment activity (3 7×10 7 Bq),the radius of tumor which can be cured is closer to the experiment result.2.If the given activity is infinitely great,the largest tumor radius which can be cured is smaller and coincide with the largest range of nuclide 32 P.So the result calculated by model 3 is fitter with the actual value than that calculated by the other two models. Conclusion\ The model 3 has considered more factors than others,so if the biological parameters are known,it could be used to calculate the TCP value under a certain kind of treatment condition to predict the internal radionuclide therapy result and estimate whether the treatment plan is reasonable.

关 键 词：肿瘤控制概率 辐射敏感性 放射性药物内照射治疗 克隆源性细胞 肿瘤 放射疗法 

分 类 号：R730.5[医药卫生—肿瘤]