2-型糖尿病病人唾液分泌功能与血糖状态间的关系  

The relationship between salivary function and glycemic control in patients with diabetes

作　　者：郝京梅[1] 杨宗萍[1] 

机构地区：[1]北京大学第一医院口腔科,100034

出　　处：《现代口腔医学杂志》2001年第5期373-374,共2页Journal of Modern Stomatology

摘　　要：目的　探讨老年糖尿病病人及血糖的控制对唾液分泌功能的影响。方法　对 38例 2 -型糖尿病及无糖尿病患者 31例 ,在空腹下测定静止唾液总流率及咀嚼白蜡动态唾液总流率 ,并测定他们的唾液免疫球蛋白 ,所有患者都进行口干问卷回答。结果　静态总流率 :血糖非控制组为 0 .2 2 6± 0 .185ml/min ,血糖控制组为 0 .45 7±0 .2 0 9ml/min ,正常对照组为 0 .5 35± 0 .2 18ml/min ,动态唾液总流率 :血糖非控制组为 0 .785± 0 .32 5ml/min ,血糖控制组为 0 .12 2± 0 .44 3ml/min ,正常对照组为 0 .133± 0 .5 6 4ml/min。糖尿病组的唾液总蛋白IgA ,IgG ,IgM与正常对照组相比无显著性差异 (P >0 .0 5 )。有关口干问卷的回答 ,两组间也无显著性差异。结论　在老年糖尿病患者中 。Objective To investigate the effect of diabetes and glycemic control on salivary function in patients with diabetes.Methods Thirty eight patients with type 2 diabetes and thirty one nondiabetic control participated (age range,53-78 years) in the present study.Diabetic status was determined by a glycosylated hemoglobin (HbA 1C ) test and a 2-hour glucose tolerance test.Poor glycemic control was defined as HbA 1C >8%.Unstimulated whole saliva and stimulated whole saliva rates on chewing medical paraffin were measured,The concentration and total value of immunoglobulins in mix saliva were examined,and subjects completed a standardized xerostomia questionnaire.Results Patients with poorly controled diabetes had lower stimnlated whole saliva flow rates than those with well controled diabetes and nondiabetic control subjects.There were no significant differences in saliva,totle protein IgA IgG IgM and xerostomic complains based on glycemic control status.Conclusion These results provide some evidence that pooly controled diabetes may be associated with salivary dysfunction in older adults.

关 键 词：2型糖尿病 血糖状态 唾液分泌 口腔干燥 

分 类 号：R781.64[医药卫生—口腔医学]