四-邻苯二甲酰亚胺甲基酞菁锌的两种合成方法比较  

Compare Two Methods for Synthesis of Phthalimidomethyl Phthalocyanine Zinc

作　　者：彭亦如[1,2,3] 林志鹏[1,3] 薛金萍[1,3] 陈耐生 黄金陵[1,3] 

机构地区：[1]福州大学功能材料研究所,化学化工学院 [2]福建师范大学化学系,福州350007 [3]中国科学院福建物质结构研究所国家重点实验室,福州350002

出　　处：《无机化学学报》2002年第3期321-324,共4页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金资助项目(No.29871008);福建省自然科学基金资助项目(No.C0110006);福建省教委资助项目(No.JA01020)

摘　　要：Molecular precursors phthalimidomethyl phthalic acid and phthalimidomethyl phthalonitrile were synthesized for the first time and both were able to condensation to form tetra phthalimidomethyl phthalocyanine zinc through “ammomium molybdate method” and “DBU method ”respectively. The precursors and title compounds were characterized by element analysis, IR, UV/Vis as well as NMR. The two synthesis methods were compared, the result indicated that using the phthalimidomethyl phthalic acid as precursor through the former method, the product was an isomer with C4h symmetry, while using phthalimidomethyl phthalonitrile as precursor through the latter method, the products were a mixture of different isomers.Molecular precursors phthalimidomethyl phthalic acid and phthalimidomethyl phthalonitrile were synthesized for the first time and both were able to condensation to form tetra phthalimidomethyl phthalocyanine zinc through “ammomium molybdate method” and “DBU method ”respectively. The precursors and title compounds were characterized by element analysis, IR, UV/Vis as well as NMR. The two synthesis methods were compared, the result indicated that using the phthalimidomethyl phthalic acid as precursor through the former method, the product was an isomer with C4h symmetry, while using phthalimidomethyl phthalonitrile as precursor through the latter method, the products were a mixture of different isomers.

关 键 词：酞菁锌配合物 合成方法 表征 四-邻苯二甲酰亚胺甲基酞菁锌 光动力治疗 荧光定位诊断 钼酸铵法 DBU法 肿瘤 光敏剂 

分 类 号：R73[医药卫生—肿瘤] R979.1[医药卫生—临床医学]