新型含磷酰基的脂溶性自由基捕捉剂的合成及其ESR研究  

Synthesis and ESR Study of a Novel Phosphorylated Lipophilic Spin-trap

作　　者：徐英凯[1] 陈中伟[1] 孙健[1] 刘科[1] 陈巍[1] 施伟[1] 王红梅[1] 张兴康[1] 刘扬[1] 

机构地区：[1]中国科学院化学研究所分子科学研究中心,分子动态和稳态结构国家重点实验室,北京100080

出　　处：《高等学校化学学报》2002年第2期333-335,共3页Chemical Journal of Chinese Universities

基　　金：国家重点基础规划项目 (批准号 :G19980 10 10 0 );国家自然科学基金 (批准号 :39890 390 ;39870 2 0 8)资助

摘　　要：Synthesis of a novel α phosphorus containing spin trap, DEPPEPO[5 (diethoxyphosphoryl) 5 phenylethyl 1 pyrroline] N oxide and evaluation of its ability to spin trap the hydroxyl and the superoxide anion radicals were described in the present article. The ability for trapping an active superoxide anion radicals generated in the HX/XO system and the stability of their spin adduct of DEPPEPO were analyzed. In addition, the effects of 5 phenylethyl and 5 phenyl substituted analogues of DMPO on the stereochemistry of the corresponding spin adducts were systematically illustrated.Synthesis of a novel α phosphorus containing spin trap, DEPPEPO[5 (diethoxyphosphoryl) 5 phenylethyl 1 pyrroline] N oxide and evaluation of its ability to spin trap the hydroxyl and the superoxide anion radicals were described in the present article. The ability for trapping an active superoxide anion radicals generated in the HX/XO system and the stability of their spin adduct of DEPPEPO were analyzed. In addition, the effects of 5 phenylethyl and 5 phenyl substituted analogues of DMPO on the stereochemistry of the corresponding spin adducts were systematically illustrated.

关 键 词：自旋捕捉 电子自旋共振 超氧阴离子自由基 脂溶性自由基捕捉剂 检测 5-(二乙氧磷酰基)-5-苯乙基-1-吡咯啉N-氧化物 

分 类 号：R446.1[医药卫生—诊断学] R362[医药卫生—临床医学]