羊膜联合自体角膜缘上皮移植重建严重碱烧伤的兔眼表面  

Ocular surface reconstruction in severe alkali burned rabbits with human aminon and autograft of limbal epithelia

作　　者：于颖[1] 阎筠[1] 杜志山[2] 鲍震[1] 张虹[1] 

机构地区：[1]天津公安医院眼科,300042 [2]天津宝坻县医院眼科

出　　处：《眼科研究》2001年第4期319-321,共3页Chinese Ophthalmic Research

摘　　要：目的　　探讨利用甘油保存的人羊膜联合自体角膜缘上皮移植，在重建严重碱烧伤后眼表面中的作用。方法 将右眼被碱严重烧伤的新西兰白兔２０只２０眼随机分为３组：甲组６眼，单纯角结膜病灶切除；乙组７眼，联合羊膜移植；丙组７眼，联合羊膜及自体角膜缘上皮移植。结果　　术后乙组 １４～１８天（平均 １４．２０天）、两组６～８天（平均７．６０天）角膜表面上皮完全覆盖，二者在术后临床愈合过程中差异有显著性（ Ｐ＜ ０．０５），抑制新生血管的作用丙组优于乙组。结论　　人羊膜联合角膜缘上皮移植重建角膜基底膜和角膜缘部结构治疗碱烧伤后的角结膜损伤是一种合理有效的治疗方法。Objective To inquire into the effect of reconstruction the surface after the rabbits keratoconjunction were severe alkali burned by transplantation of glycerin preserved human amnion unite autograft limbal epithlium. Methods 20 eyes of 20 New Zealand rabbits each were severe alkali burned. They were devided into three groups: A group(n = 6 ) simply reseived a keratoconjunctional focus; B Group(n = 7 ) transplantated human amnion; C group(n = 7 ) transplant human amnion unite limbal epithelium. Resault Corneal surface was entirely covered by epitheliun on 14 ~ 18 d (average 14. 2 d) in group B, about 6 ~ 8 d(average 6. 8 d) of group C postoperatively (P < 0. 05 ). The effect of inhibit neovascularization in group C was superior than group B. Conclusion Reconstruction comeal basic membrane and limbal through transplantation human amnion unite autograft of limbal epithelium is a reasonable and effective treatment for keratoconjunctive damage caused by severe alkali burn.

关 键 词：人羊膜 角膜缘上皮 眼化学伤 角膜移植 动物实验 

分 类 号：R779.13[医药卫生—眼科]