5-氟尿嘧啶与丝裂霉素C在青光眼滤过术中的合理应用  

Aplication of mitomycin C and 5-Fluorouracil in the glaucoma filtering surgery

作　　者：陈新宇[1] 刘晓宁[1] 吴登雷[1] 

机构地区：[1]江苏省镇江市第一人民医院眼科,212002

出　　处：《眼科研究》2001年第4期347-349,共3页Chinese Ophthalmic Research

摘　　要：目的　探讨青光眼滤过手术抗代谢药物丝裂霉素Ｃ（ＭＣＣ）与５－氟尿嘧啶（５－Ｆｕ）的合理应用。方法　对１０８只需手术的青光眼随机分成 ３组。 ５－Ｆｕ组术后球结膜下注射 ５－Ｆｕ６～８次，ＭＭＣ组术中一次性给予质量浓度为０．２ ｍｇ／ｍｌ的 ＭＭＣ，对照组则不用任何药物，观察各组术后的疗效及并发症。结果　随访 ３～３４个月（平均 ２８． ２月），５－Ｆｕ和ＭＭＣ组手术成功率明显高于对照组，Ｐ＜０．０５，术后并发症５－Ｆｕ组角膜上皮点状损害１８只眼（４５％），ＭＭＣ组低眼压２例（６．７％），与对照组比有显著差异（Ｐ＜０．０５）。结论５－Ｆｕ与ＭＭＣ能提高青光眼手术的成功率，但有一定的毒副作用。临床上应根据病人的年龄、病情及青光眼类型选择用药。Objective To evaluate the proper application of mytomycin C (MMC) and 5-Fluorouracil (5-Fu ) in glaucoma filtering surgery. Methods 98 cases(108 eyes) were randowly divided into three groups, including 30 eyes in MMC group,40 eyes in 5-Fu group and 38 eyes in control group. 0. 2mg/ml MMC was used during the trabeculectomy in MMC group. 5-Fu(5mg) was injected subcojunclivally for 6~8 times post-operatively in 5-Fu group. No drug was used in the control group. The follow-up period was from 3 to 34 months (mean 28. 2 months). Results The successful rate of MMC (93. 3% ) and 5-Fu (82. 5% ) groups were higher than that of control group(52. 6% ) (P < 0. 05 ). The main complications were corneal damage in 5-Fu group and low intraocular pressure in MMC group. Conclusions 5-Fu and MMC can elevate the successful rate of filtering surgery. Because of the side-effects,the drug should be used according to the patient's condintion.

关 键 词：5-氟尿嘧啶 线裂霉素C 青光眼 滤过手术 眼外科手术 

分 类 号：R779.6[医药卫生—眼科]