CYP450s体外重组技术及在药物代谢和安全性评价中的应用  

Recombinant in vitro tools to predict drug metabolism and safety

作　　者：王海学[1] 邓巧琳[1] 李端[1] 

机构地区：[1]复旦大学药学院药理学教研室,上海,200032

出　　处：《中国药理学通报》2001年第6期621-624,共4页Chinese Pharmacological Bulletin

摘　　要：药物代谢是在代谢酶催化下完成的 ,它决定着药物的药理学和毒理学特性。根据动物实验来预测人体的药物代谢时 ,代谢酶的种属差异性会使这项研究工作变得非常困难。本文对含有人体代谢酶系的重组技术模型的应用进行了介绍和评价。Drug metabolism determines several pharmacological and toxicological properties of pharmaceuticals and is catalyzed by drug metabolizing enzymes. Predicting of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes. This review describes and evaluates the use of recombinant models that contain human drug metabolizing enzymes to facilitate the prediction of pharmacokinetical properties of candidate drugs in humans.

关 键 词：重组技术 CYP450 药物代谢 安全性 药理学 

分 类 号：R965.3[医药卫生—药理学]