电化学疗法对小鼠淋巴瘤生长的实验研究  

Experimental Study on Electrochemotherapy (ECT) of Malignant Lymphoma (L-TA2)

作　　者：张文霞[1] 孙慧[2] 吴杰 李文 多耀祥[1] 王志光[1] 李莉[1] 

机构地区：[1]天津医科大学生理教研室,天津市300070 [2]天津市肿瘤研究所实验肿瘤室

出　　处：《中国肿瘤临床》2001年第8期611-613,共3页Chinese Journal of Clinical Oncology

基　　金：天津市自然科学基金资助

摘　　要：目的：探讨电化学疗法对TA2系小鼠B 细胞淋巴瘤的抑制作用和死亡率的影响。方法：用移植的方法复制小鼠B细胞淋巴瘤模型，随后应用电脉冲通过铂金电极直接刺激肿瘤组织。1周后观察肿瘤大小、转移及存活情况。结果：电脉冲组肿瘤的生长速度、转移程度较对照组低，而死亡率明显低于对照组和化疗组，电脉冲与化疗合用抑制效果更佳。结论：电化学疗法可明显抑制肿瘤组织生长及转移，降低带瘤动物的死亡率。Objective： To study the effects of ECT on the inhibition and death rate of B－lymphoma in TA2 inbred mice． Methods： Transplatation was used to copy the B－lymphoma model in TA2 inbred mice， then electric pulse was used to stimulate the tumors through Pt electrode． Its size， metastasis and living status were observed after one week． Results： The growing velocity and metastatic status of tumor in the electric pulse group were lower than those in the control group and the mortality rate was significantly lower than those in the control and chemotherapy groups．． The inhibition effect was better when EP and chemotherapy were used together． Conclusion： By ECT， the growth and metastasis of tumor is inhibited significantly and the mortality rate of mice is lowered．

关 键 词：电化学疗法 B细胞淋巴瘤 电脉冲 COP方案 动物实验 

分 类 号：R73-36[医药卫生—肿瘤]