丙型肝炎高变区多肽的同源模建与抗原性研究  

Study on the computer modeling and the antigenicity of the HCV HVR1 peptide

作　　者：苏琴[1] 郑宇[1] 林芳[1] 赵军[1] 李伯安[1] 李静[1] 高蓉[1] 程云[1] 

机构地区：[1]解放军302医院传染病研究所免疫室,北京100039

出　　处：《细胞与分子免疫学杂志》2001年第6期527-528,共2页Chinese Journal of Cellular and Molecular Immunology

基　　金：全军95课题基金;No.96M174;98Z089

摘　　要：目的通过计算机同源模建,寻找丙型肝炎高变区中保护性多肽抗原表位。方法用计算机同源模建预测多肽的抗原性,然后用淋巴细胞转化试验验证其抗原性。结果同源模建与实验结果相一致。结论同源模建是一种高效寻找具有保护性的抗原多肽的经济快速的方法。Aim To seek out the protective polypeptide epitope of the HCV HVR1 by computer homogeneity modeling, and verify the epitope by lymphocyte transformation test. Methods The antigenicity of the synthetic peptide were predicted by the computer modeling, then verified by lymphocyte transformation test. Result The outcome of computer homogeneity modeling was in accord with our experimental results. Conclusions The computer homogeneity modeling is an economic mean by which the protective peptide can be found out quickly.

关 键 词：同源模建 保护性多肽 抗原表位 丙型肝炎 

分 类 号：R512.630.3[医药卫生—内科学]