视网膜中央动脉阻塞性缺血对黄斑区视网膜神经上皮的影响  

Effect of central retinal artery occlusion on retinal microstructure of macula in vivo

作　　者：李梅[1] 凌运兰[1] 刘杏[1] 冯官光[1] 易长贤[1] 郑小平[1] 

机构地区：[1]中山医科大学中山眼科中心,广东广州510060

出　　处：《中国病理生理杂志》2001年第8期749-751,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :应用光学相干断层扫描 (OCT)探讨视网膜中央动脉阻塞 (CRAO)性缺血对黄斑区视网膜组织结构的影响。方法 :用OCT对单眼CRAO 2 - 3d ,黄斑区视网膜血液循环未完全恢复的患者 14例 (14眼 )和 11例 (11眼 )对侧健眼进行经中心小凹的水平和垂直扫描 ,分别测量及计算中心小凹、中心凹及黄斑的平均视网膜神经上皮层 (RNL)厚度。结果 :正常眼中心小凹、中心凹及黄斑平均RNL厚度分别为 (16 9 91± 10 96 ) μm、(176 36± 11 74) μm、(2 5 6 45± 16 95 ) μm ;CRAO黄斑区RNL明显增厚 ,中心小凹、中心凹及黄斑平均RNL厚度分别为 (2 35 6 4± 47 0 2 ) μm、(2 41 84± 49 36 ) μm、(4 0 1 5 7± 5 4 5 3) μm ,与正常眼比较有显著性差异 (P <0 0 5 ,P <0 0 1)。 结论 :CRAO性缺血明显地改变了黄斑区正常视网膜组织结构 。AIM: To investigate the effect of ischemia induced by central retinal artery occlusion on retinal microstructure of macula using optical coherence tomography (OCT). METHODS: Fourteen eyes of 14 patients with unilateral central retinal artery occlusion (CRAO) in two to three days without fully recovery of retinal circulation underwent OCT examination with 4.5 mm length horizontal and vertical line scans through foveola to measure the retinal neurosensory layer (RNL) thickness on foveola, 175 μm (fovea), 750 μm (macula) to foveola, respectively. The other normal eyes of patients as control group underwent the same examination and measurement. RESULTS: The mean RNL thickness(μm) on foveola, fovea, macula were 169 91±10 96, 176 36±11 74 and 256 45±16 95 respectively in normal control eyes, and 235 64±47 02 , 241 84±49 36 and 401 57±54 53 respectively in CRAO eyes with retinal ischemia. There was a significant difference in thickness between two group ( P<0.05, P< 0.01). CONCLUSION: Retinal microstructure of macula significantly changed in ischemia eyes with CRAO.

关 键 词：黄斑 体层摄影术 视网膜中央动脉阻塞性缺血 视网膜神经上皮 病理 

分 类 号：R774.5[医药卫生—眼科]