血管生成与胃癌浸润关系的研究  

RELATIONSHIP BETWEEN TUMOR ANGIOGENESIS AND INVASION OF GASTRIC CARCINOMA

作　　者：刘志明[1] 姜海行[1] 韩萍[1] 蒋一强[1] 葛莲英[2] 肖强[1] 

机构地区：[1]广西医科大学第一附属医院,南宁530021 [2]广西医科大学附属肿瘤医院,南宁530021

出　　处：《广西医科大学学报》2001年第6期808-809,共2页Journal of Guangxi Medical University

摘　　要：目的 :探讨血管生成与胃癌发生、发展的关系。方法 :应用免疫组织化学方法检测 76例胃癌组织血管内皮细胞生长因子 (VEGF)与微血管密度 (MVD)表达 ,分析 VEGF和 MVD表达与胃癌各临床病理指标之间的关系。结果 :76例胃癌组织中 VEGF表达阳性率为 38.2 % (2 9/ 76 ) ;VEGF表达阳性肿瘤的 MVD明显高于阴性者 (P <0 .0 5 ) ,高水平的 VEGF表达与肿瘤浸润程度、淋巴结转移和肝转移具有明显相关关系。结论 :VEGF与胃癌的血管生成密切相关 ,对胃癌的生长和浸润转移有促进作用 ,VEGF和 MVD可作为反映胃癌生物学行为的指标之一。Objective:To explore the relationship between tumor angiogenesis and invasion of gastric carcinoma Method:Expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) was examined immunolistochemically in 76 gastric carcinoma specimens respectively Results:38 2% of the 76 gastric carcinoma specimens were positive for VEGF, A close correlation was present between microvessel density and VEGF positivity (P<0 05) High VEGF expression was significantly correlated with the invasive depth, lymph node and liver metastasis Conclusions:The results of this study suggest that VEGF expression is associated with tumor progression by stimulating angiogenesis in gastric carcinoma

关 键 词：胃肿瘤 新生血管化 内皮生长因子 

分 类 号：R735.2[医药卫生—肿瘤]