脑梗死急性期患者凝血与纤溶指标的改变及降纤酶的疗效  

Change of fibrinolytic system and clotting index in patients with acute brain infarction and influence of defibrinogenase therapy

作　　者：林庆兰[1] 郭秋杰[1] 曾寰[1] 

机构地区：[1]福建省厦门市第二医院,福建厦门361002

出　　处：《心血管康复医学杂志》2002年第1期19-21,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的 :研究脑梗死急性期患者纤溶、凝血指标的变化及降纤酶的疗效。方法 :测定 38例脑梗死急性期 (<3天 )患者降纤酶治疗前、后的血浆纤维蛋白原 (Fbg)、α2 抗纤溶酶 (α2 - PI)、血浆组织型纤溶酶原激活物 (t- PA)及其抑制物 (PAI- 1)和 D-二聚体 (D- D)的变化。结果 :脑梗死急性期患者血浆 Fbg、α2 - PI、 PAI- 1、 D- D水平分别为 4.32± 1.7g/ L、 (15 4.39± 34 .86 ) %、 0 .2 6± 0 .1IU/ m l、 1.12± 0 .32 AU/ ml和 1.34± 1.18mg/ L,明显升高 ,较正常对照组有显著差异 P<0 .0 1) ,t- PA水平下降非常显著 (P<0 .0 0 1)。降纤酶治疗后 Fbg、α2 - PI、 PAI- 1、 D- D水平显著下降 (P<0 .0 5～ P<0 .0 0 1) ,t- PA水平升高非常显著 (P<0 .0 0 1)。结论 :降纤酶有良好降纤、溶纤作用 ,对脑梗死急性期患者有显著疗效。Objective:To study the changes of fibrinolytic and clotting system in patients with acute brain infarction (ABI) and influence of defibrinogenase therapy.Methods: The levels of fibrinogen (Fbg)?α 2-antiplasmin (α 2-PI)?plasma issue plasminogen activator (t-PA),Plasminogen activator ingibitor-1(PAI-1),D-dimmer(D-D) were measured in 38 ABI patients within 3 days after episode.Results: The Fbg?α 2-PI?PAI-1?D-D levels of ABI patients were 4.32±1.7g/L?(154.39±34.86)%?0.26±0.1IU/ml?1.12±0.32AU/ml?1.34±1.18mg/L in order, all increased than normal control( P <0.01), the t-PA level decreased( P <0.001); Fbg?α 2-PI ?PAI-1,D-D levels significantly decreased( P<0.05 ～P <0.001), t-PA level increased( P <0.001) after defibrinogenase therapy.Conclusion:For improving function of fibrinolytic and clotting system in patients with ABI defibrinogenase therapy has obvious effect.

关 键 词：脑梗死 纤维蛋白原 血浆组织型纤溶酶原激活物 急性期 D-二聚体 降纤酶 凝血指标 纤溶指标 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R973.2[医药卫生—临床医学]