儿童髓母细胞瘤中尿激酶型纤溶酶原激活剂的表达  

Expression of urokinase-type plasminogen activator in medulloblastoma of children

作　　者：陈礼刚 秦山[2] 张伶俐[2] 曾凡俊[1] 朴永旭[1] 杨立斌[1] 罗克枢[3] 

机构地区：[1]成都军区总医院神经外科,成都610083 [2]华西医科大学附属一院,成都610043 [3]成都军区总医院病理科,成都610083

出　　处：《第四军医大学学报》2002年第2期152-154,共3页Journal of the Fourth Military Medical University

摘　　要：目的　探讨尿激酶型纤溶酶原激活剂 (urokinase-type plasminogen activator,u PA)在儿童髓母细胞中的表达及临床意义 .方法　采用免疫组化 L SAB法检测 84例经手术病理证实并获随访的儿童髓母细胞瘤 (男 46 ,女 38)例 ,年龄 6～ 12岁中的 u PA表达 ,按术后生存期 3,5 ,10 a.分为 A,B,C三组 .使用 Cox回归统计分析 .结果　 84例儿童髓母细胞瘤中 ,u PA阳性表达 44例 (5 2 % ) ,A,B,C三组间 u PA阳性表达分别为 71% ,41% ,2 0 % (P<0 .0 1) ;Cox回归分析显示u PA是影响生存时间的一个独立的预后因子 ,它与预后高度负相关 .结论　 uAIM To study expression and clinical significance of urokinase type plasminogen activator (uPA) in medul loblastoma of children. METHODS Expression of uPA in 84 cases of pathologically confirmatory and followed up medulloblastoma of children (46 males, 38 females, aged from 6 to 12 years) was detected with labelled strepatavidin biotin (LSAB). The cases were divided into 3 groups according to survival period of 3, 5, 10 a respectively. Cox regression analysis was used. RESULTS Expression positive rate of uPA was 52% (44/84), and were 71%, 41%, and 20% in group A, B, and C respectively ( P <0.01). Cox regression showed that uPA was in independent prognostic factor affecting survival and it had close negative correlation with the prognosis. CONCLUSION Expression level of uPA was closely related to predicting prognosis of medulloblastoma in children.

关 键 词：儿童 尿激酶 预后 免疫组织化学 髓母细胞瘤 血管内皮生长因子 

分 类 号：R739.4[医药卫生—肿瘤]